Alrestatin Sodium

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MedKoo CAT#: 561242

CAS#: 51876-97-2 (sodium)

Description: Alrestatin is a specific inhibitor of the aldose reductase enzyme. Alrestatin also inhibited gastric acid secretion and decreased the volume of gastric juice produced in pylorus-ligated rats. It is structurally related to tolrestat, another ARI that was briefly marketed before being withdrawn in 1997.

Chemical Structure

Alrestatin Sodium
CAS# 51876-97-2 (sodium)

Theoretical Analysis

MedKoo Cat#: 561242
Name: Alrestatin Sodium
CAS#: 51876-97-2 (sodium)
Chemical Formula: C14H8NNaO4
Exact Mass:
Molecular Weight: 277.21
Elemental Analysis: C, 60.66; H, 2.91; N, 5.05; Na, 8.29; O, 23.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 51876-97-2 (sodium)   51411-04-2 (free acid)    

Synonym: Alrestatin Sodium; Alrestatine sodium; AY-22284A; AY 22284A; AY22284A

IUPAC/Chemical Name: Sodium 2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)acetate


InChi Code: InChI=1S/C14H9NO4.Na/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19;/h1-6H,7H2,(H,16,17);/q;+1/p-1

SMILES Code: O=C([O-])CN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 277.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lippmann W, Seethaler K, Borella LE, Pugsley TA. Alrestatin: gastric acid antisecretory-antiulcer activity in the rat. Digestion. 1978;18(1-2):35-44. PubMed PMID: 103765.

2: Kobric M, Lippmann W. Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat. Horm Metab Res. 1978 Nov;10(6):495-500. PubMed PMID: 744568.

3: Srivastava SK, Ansari NH, Bhatnagar A, Hair G, Liu S, Das B. Activation of aldose reductase by nonenzymatic glycosylation. Prog Clin Biol Res. 1989;304:171-84. PubMed PMID: 2506561.

4: Brogard JM, Caro-Sampara F, Blicklé JF. [Role of polyols in the development of diabetic complications. Value of aldose-reductase inhibitors]. Rev Med Interne. 1992 Jan-Feb;13(1):69-79. Review. French. PubMed PMID: 1410879.

5: Morjana NA, Flynn TG. Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors. J Biol Chem. 1989 Feb 15;264(5):2906-11. PubMed PMID: 2492526.

6: Das B, Srivastava SK. Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte. Arch Biochem Biophys. 1985 May 1;238(2):670-9. PubMed PMID: 3922304.

7: Cromlish JA, Flynn TG. Purification and characterization of two aldose reductase isoenzymes from rabbit muscle. J Biol Chem. 1983 Mar 10;258(5):3416-24. PubMed PMID: 6402510.