WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561242
CAS#: 51876-97-2 (sodium)
Description: Alrestatin is a specific inhibitor of the aldose reductase enzyme. Alrestatin also inhibited gastric acid secretion and decreased the volume of gastric juice produced in pylorus-ligated rats. It is structurally related to tolrestat, another ARI that was briefly marketed before being withdrawn in 1997.
MedKoo Cat#: 561242
Name: Alrestatin Sodium
CAS#: 51876-97-2 (sodium)
Chemical Formula: C14H8NNaO4
Molecular Weight: 277.21
Elemental Analysis: C, 60.66; H, 2.91; N, 5.05; Na, 8.29; O, 23.09
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Alrestatin Sodium; Alrestatine sodium; AY-22284A; AY 22284A; AY22284A
IUPAC/Chemical Name: Sodium 2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)acetate
InChi Key: FKZUETPACPDEAD-UHFFFAOYSA-M
InChi Code: InChI=1S/C14H9NO4.Na/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19;/h1-6H,7H2,(H,16,17);/q;+1/p-1
SMILES Code: O=C([O-])CN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 277.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lippmann W, Seethaler K, Borella LE, Pugsley TA. Alrestatin: gastric acid antisecretory-antiulcer activity in the rat. Digestion. 1978;18(1-2):35-44. PubMed PMID: 103765.
2: Kobric M, Lippmann W. Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat. Horm Metab Res. 1978 Nov;10(6):495-500. PubMed PMID: 744568.
3: Srivastava SK, Ansari NH, Bhatnagar A, Hair G, Liu S, Das B. Activation of aldose reductase by nonenzymatic glycosylation. Prog Clin Biol Res. 1989;304:171-84. PubMed PMID: 2506561.
4: Brogard JM, Caro-Sampara F, Blicklé JF. [Role of polyols in the development of diabetic complications. Value of aldose-reductase inhibitors]. Rev Med Interne. 1992 Jan-Feb;13(1):69-79. Review. French. PubMed PMID: 1410879.
5: Morjana NA, Flynn TG. Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors. J Biol Chem. 1989 Feb 15;264(5):2906-11. PubMed PMID: 2492526.
6: Das B, Srivastava SK. Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte. Arch Biochem Biophys. 1985 May 1;238(2):670-9. PubMed PMID: 3922304.
7: Cromlish JA, Flynn TG. Purification and characterization of two aldose reductase isoenzymes from rabbit muscle. J Biol Chem. 1983 Mar 10;258(5):3416-24. PubMed PMID: 6402510.