WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571015
Description: A 1110U is an inactivator of herpes simplex virus ribonucloetide reductases. It has been shown to be synergistic with acyclovir to produce chemotherapeutic effects on herpes skin lesions.
MedKoo Cat#: 571015
Name: A 1110U
Chemical Formula: C11H16N6S2
Exact Mass: 296.0878
Molecular Weight: 296.41
Elemental Analysis: C, 44.57; H, 5.44; N, 28.35; S, 21.63
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: A 1110U, A-1110U, A1110U
IUPAC/Chemical Name: Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-
InChi Key: RPMMBVWROKDIKM-MDWZMJQESA-N
InChi Code: InChI=1S/C11H16N6S2/c1-8(9-6-4-5-7-12-9)13-14-10(18)15-16-11(19)17(2)3/h4-7H,1-3H3,(H,16,19)(H2,14,15,18)/b13-8+
SMILES Code: S=C(N/N=C(C1=NC=CC=C1)\C)NNC(N(C)C)=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 296.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Porter DJ, Harrington JA, Spector T. Herpes simplex virus type 1
ribonucleotide reductase: selective and synergistic inactivation by A1110U and
its iron complex. Biochem Pharmacol. 1990 Feb 15;39(4):639-46. PubMed PMID:
2: Ellis MN, Lobe DC, Spector T. Synergistic therapy by acyclovir and A1110U for
mice orofacially infected with herpes simplex viruses. Antimicrob Agents
Chemother. 1989 Oct;33(10):1691-6. PubMed PMID: 2556074; PubMed Central PMCID:
3: Spector T, Harrington JA, Porter DJ. Herpes and human ribonucleotide
reductases. Inhibition by 2-acetylpyridine
5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87). Biochem
Pharmacol. 1991 Jun 21;42(1):91-6. PubMed PMID: 1648925.
4: Spector T, Harrington JA, Morrison RW Jr, Lambe CU, Nelson DJ, Averett DR,
Biron K, Furman PA. 2-Acetylpyridine
5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent
inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster
viruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A. 1989
Feb;86(3):1051-5. PubMed PMID: 2536930; PubMed Central PMCID: PMC286619.
5: Lobe DC, Spector T, Ellis MN. Synergistic topical therapy by acyclovir and
A1110U for herpes simplex virus induced zosteriform rash in mice. Antiviral Res.
1991 Feb;15(2):87-100. PubMed PMID: 1650166.
6: Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM. Inactivators of
herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo
potentiation of the antiviral activity of acyclovir. Antimicrob Agents Chemother.
1992 May;36(5):934-7. PubMed PMID: 1324641; PubMed Central PMCID: PMC188768.