A 1110U

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571015

CAS#: 96860-23-0

Description: A 1110U is an inactivator of herpes simplex virus ribonucloetide reductases. It has been shown to be synergistic with acyclovir to produce chemotherapeutic effects on herpes skin lesions.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

A 1110U is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571015
Name: A 1110U
CAS#: 96860-23-0
Chemical Formula: C11H16N6S2
Exact Mass: 296.0878
Molecular Weight: 296.41
Elemental Analysis: C, 44.57; H, 5.44; N, 28.35; S, 21.63

Synonym: A 1110U, A-1110U, A1110U

IUPAC/Chemical Name: Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-


InChi Code: InChI=1S/C11H16N6S2/c1-8(9-6-4-5-7-12-9)13-14-10(18)15-16-11(19)17(2)3/h4-7H,1-3H3,(H,16,19)(H2,14,15,18)/b13-8+


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Porter DJ, Harrington JA, Spector T. Herpes simplex virus type 1
ribonucleotide reductase: selective and synergistic inactivation by A1110U and
its iron complex. Biochem Pharmacol. 1990 Feb 15;39(4):639-46. PubMed PMID:

2: Ellis MN, Lobe DC, Spector T. Synergistic therapy by acyclovir and A1110U for
mice orofacially infected with herpes simplex viruses. Antimicrob Agents
Chemother. 1989 Oct;33(10):1691-6. PubMed PMID: 2556074; PubMed Central PMCID:

3: Spector T, Harrington JA, Porter DJ. Herpes and human ribonucleotide
reductases. Inhibition by 2-acetylpyridine
5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87). Biochem
Pharmacol. 1991 Jun 21;42(1):91-6. PubMed PMID: 1648925.

4: Spector T, Harrington JA, Morrison RW Jr, Lambe CU, Nelson DJ, Averett DR,
Biron K, Furman PA. 2-Acetylpyridine
5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent
inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster
viruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A. 1989
Feb;86(3):1051-5. PubMed PMID: 2536930; PubMed Central PMCID: PMC286619.

5: Lobe DC, Spector T, Ellis MN. Synergistic topical therapy by acyclovir and
A1110U for herpes simplex virus induced zosteriform rash in mice. Antiviral Res.
1991 Feb;15(2):87-100. PubMed PMID: 1650166.

6: Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM. Inactivators of
herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo
potentiation of the antiviral activity of acyclovir. Antimicrob Agents Chemother.
1992 May;36(5):934-7. PubMed PMID: 1324641; PubMed Central PMCID: PMC188768.