WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530682
Description: YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. Pharmacologic inhibition of SIK sends HDAC4 to the nucleus and inhibits the calcification process in VSMCs, aortic rings, and in vivo In the cytoplasm, HDAC4 binds and its activity depends on the adaptor protein ENIGMA (Pdlim7) to promote vascular calcification.
MedKoo Cat#: 530682
Chemical Formula: C30H37N7O2
Exact Mass: 527.3009
Molecular Weight: 527.673
Elemental Analysis: C, 68.29; H, 7.07; N, 18.58; O, 6.06
Synonym: YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061.
IUPAC/Chemical Name: 1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
InChi Key: GVBAXIVNAHMIGH-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H37N7O2/c1-20-7-5-8-21(2)27(20)36-19-22-18-31-29(33-28(22)37(30(36)38)23-9-6-10-23)32-25-12-11-24(17-26(25)39-4)35-15-13-34(3)14-16-35/h5,7-8,11-12,17-18,23H,6,9-10,13-16,19H2,1-4H3,(H,31,32,33)
SMILES Code: O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C