WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561207
CAS#: 54156-23-9 (HCl)
Description: K118 is a water soluble inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). K118 reverses age- and diet-associated obesity and metabolic syndrome.
MedKoo Cat#: 561207
Name: K118 HCl
CAS#: 54156-23-9 (HCl)
Chemical Formula: C19H34ClN
Exact Mass: 311.238
Molecular Weight: 311.94
Elemental Analysis: C, 73.16; H, 10.99; Cl, 11.36; N, 4.49
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 54156-22-8 (free base) 54156-23-9 (HCl)
Synonym: K118; K 118; K-118; K118 HCl; K118 hydrochloride
IUPAC/Chemical Name: (3S,5S,8S,9S,10S,13S,14S)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-amine hydrochloride
InChi Key: YRFZFBDCFRITSB-NKPAQCGESA-N
InChi Code: InChI=1S/C19H33N.ClH/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18;/h13-17H,3-12,20H2,1-2H3;1H/t13-,14-,15-,16-,17-,18-,19-;/m0./s1
SMILES Code: N[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CCC4)C1.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 311.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902. PubMed PMID: 25402778.
2: Srivastava N, Iyer S, Sudan R, Youngs C, Engelman RW, Howard KT, Russo CM, Chisholm JD, Kerr WG. A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome. JCI Insight. 2016 Jul 21;1(11). pii: e88544. PubMed PMID: 27536730; PubMed Central PMCID: PMC4985248.