Quercetin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329688

CAS#: 17-39-5 (quercetin)

Description: Quercetin is a plant polyphenol from the flavonoid group, found in many fruits, vegetables, leaves, and grains. It can be used as an ingredient in supplements, beverages, or foods. Quercetin has been reported to inhibit the oxidation of other molecules and hence is classified as an antioxidant. Quercetin contains a polyphenolic chemical substructure that stops oxidation by acting as a scavenger of free radicals that are responsible for oxidative chain reactions. Quercetin also activates or inhibits the activities of a number of proteins.


Price and Availability

Size
Price

50g
USD 150
Size
Price

100g
USD 250
Size
Price

Quercetin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329688
Name: Quercetin
CAS#: 17-39-5 (quercetin)
Chemical Formula: C15H10O7
Exact Mass: 302.0427
Molecular Weight: 302.238
Elemental Analysis: C, 59.61; H, 3.34; O, 37.05


Related CAS #: 482-35-9 (EMIQ)   482-35-9 (Isoquercetin)   17-39-5 (quercetin)    

Synonym: Kvercetin; Meletin; NCI-C60106; NSC 9219; NSC 9221; Quercetin; Quercetine; Quercetol; Quertine; Sophoretin; Xanthaurine.

IUPAC/Chemical Name: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one

InChi Key: REFJWTPEDVJJIY-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

SMILES Code: O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Quercetin has been studied in basic research and small clinical trials. While quercetin supplements have been promoted for the treatment of cancer and various other diseases, there is no evidence that quercetin (via supplements or in food) is useful to treat cancer or any disease. The US FDA has issued warning letters to emphasize that quercetin is neither a defined nutrient nor an antioxidant, cannot be assigned a dietary content level, and is not regulated as a drug to treat any human disease.


References

1: Massi A, Bortolini O, Ragno D, Bernardi T, Sacchetti G, Tacchini M, De Risi C. Research Progress in the Modification of Quercetin Leading to Anticancer Agents. Molecules. 2017 Jul 29;22(8). pii: E1270. doi: 10.3390/molecules22081270. Review. PubMed PMID: 28758919.

2: Marunaka Y. Actions of quercetin, a flavonoid, on ion transporters: its physiological roles. Ann N Y Acad Sci. 2017 Jun;1398(1):142-151. doi: 10.1111/nyas.13361. Epub 2017 Jun 2. Review. PubMed PMID: 28574574.

3: Mohammadi-Sartang M, Mazloom Z, Sherafatmanesh S, Ghorbani M, Firoozi D. Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2017 May 24. doi: 10.1038/ejcn.2017.55. [Epub ahead of print] Review. PubMed PMID: 28537580.

4: Terao J. Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function. Biochem Pharmacol. 2017 Apr 2. pii: S0006-2952(17)30183-1. doi: 10.1016/j.bcp.2017.03.021. [Epub ahead of print] Review. PubMed PMID: 28377278.

5: Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules. 2017 Jan 29;22(2). pii: E209. doi: 10.3390/molecules22020209. Review. PubMed PMID: 28146071.

6: Zizkova P, Stefek M, Rackova L, Prnova M, Horakova L. Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases. Chem Biol Interact. 2017 Mar 1;265:36-46. doi: 10.1016/j.cbi.2017.01.019. Epub 2017 Jan 28. Review. PubMed PMID: 28137512.

7: Xia T, Eiteman MA. Quercetin Glucoside Production by Engineered Escherichia coli. Appl Biochem Biotechnol. 2017 Aug;182(4):1358-1370. doi: 10.1007/s12010-017-2403-x. Epub 2017 Jan 19. Review. PubMed PMID: 28102518.

8: Anand David AV, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016 Jul-Dec;10(20):84-89. doi: 10.4103/0973-7847.194044. Review. PubMed PMID: 28082789; PubMed Central PMCID: PMC5214562.

9: McKay TB, Karamichos D. Quercetin and the ocular surface: What we know and where we are going. Exp Biol Med (Maywood). 2017 Mar;242(6):565-572. doi: 10.1177/1535370216685187. Epub 2017 Jan 5. Review. PubMed PMID: 28056553.

10: Chen S, Jiang H, Wu X, Fang J. Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes. Mediators Inflamm. 2016;2016:9340637. doi: 10.1155/2016/9340637. Epub 2016 Nov 28. Review. PubMed PMID: 28003714; PubMed Central PMCID: PMC5149671.

11: Parvaresh A, Razavi R, Rafie N, Ghiasvand R, Pourmasoumi M, Miraghajani M. Quercetin and ovarian cancer: An evaluation based on a systematic review. J Res Med Sci. 2016 May 9;21:34. eCollection 2016. Review. PubMed PMID: 27904580; PubMed Central PMCID: PMC5122222.

12: Harris Z, Donovan MG, Branco GM, Limesand KH, Burd R. Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy. Front Nutr. 2016 Oct 31;3:48. eCollection 2016. Review. PubMed PMID: 27843913; PubMed Central PMCID: PMC5086580.

13: Oboh G, Ademosun AO, Ogunsuyi OB. Quercetin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;929:377-387. Review. PubMed PMID: 27771934.

14: Suganthy N, Devi KP, Nabavi SF, Braidy N, Nabavi SM. Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions. Biomed Pharmacother. 2016 Dec;84:892-908. doi: 10.1016/j.biopha.2016.10.011. Epub 2016 Oct 15. Review. PubMed PMID: 27756054.

15: Eid HM, Haddad PS. The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Curr Med Chem. 2017;24(4):355-364. doi: 10.2174/0929867323666160909153707. Review. PubMed PMID: 27633685.

16: Khan F, Niaz K, Maqbool F, Ismail Hassan F, Abdollahi M, Nagulapalli Venkata KC, Nabavi SM, Bishayee A. Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update. Nutrients. 2016 Aug 29;8(9). pii: E529. doi: 10.3390/nu8090529. Review. PubMed PMID: 27589790; PubMed Central PMCID: PMC5037516.

17: Hatahet T, Morille M, Hommoss A, Devoisselle JM, Müller RH, Bégu S. Quercetin topical application, from conventional dosage forms to nanodosage forms. Eur J Pharm Biopharm. 2016 Nov;108:41-53. doi: 10.1016/j.ejpb.2016.08.011. Epub 2016 Aug 24. Review. PubMed PMID: 27565033.

18: Kashyap D, Mittal S, Sak K, Singhal P, Tuli HS. Molecular mechanisms of action of quercetin in cancer: recent advances. Tumour Biol. 2016 Oct;37(10):12927-12939. Epub 2016 Jul 22. Review. PubMed PMID: 27448306.

19: Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016 May 12;21(5). pii: E623. doi: 10.3390/molecules21050623. Review. PubMed PMID: 27187333.

20: Yan SX, Li X, Sun CD, Chen KS. [Hypoglycemic and hypolipidemic effects of quercetin and its glycosides]. Zhongguo Zhong Yao Za Zhi. 2015 Dec;40(23):4560-7. Review. Chinese. PubMed PMID: 27141664.