Swertiamarin
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MedKoo CAT#: 561201

CAS#: 17388-39-5

Description: Swertiamarin is an active compound isolated from Enicostemma littorale possesses antidiabetic activity and enhances β cell regeneration which causes reversal of diabetes. Swertiamarin possesses antihyperglycemic, antihyperlipidemic, cytoprotective, and immune reactivity and also a broad spectrum potential of treating diabetes and other complications related to diabetes.


Chemical Structure

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Swertiamarin
CAS# 17388-39-5

Theoretical Analysis

MedKoo Cat#: 561201
Name: Swertiamarin
CAS#: 17388-39-5
Chemical Formula: C16H22O10
Exact Mass: 374.1213
Molecular Weight: 374.342
Elemental Analysis: C, 51.34; H, 5.92; O, 42.74

Price and Availability

Size Price Availability Quantity
25.0mg USD 285.0 2 Weeks
50.0mg USD 450.0 2 Weeks
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Synonym: Swertiamarin; Swertiamaroside

IUPAC/Chemical Name: (3S,4R,4aR)-4-ethenyl-4a-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[3,4-c]pyran-8-one

InChi Key: HEYZWPRKKUGDCR-QBXMEVCASA-N

InChi Code: InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2/t7-,9+,10+,11-,12+,14-,15-,16+/m0/s1

SMILES Code: O=C1OCC[C@]2(O)C1=CO[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2C=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 374.342 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Leong XY, Thanikachalam PV, Pandey M, Ramamurthy S. A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases. Biomed Pharmacother. 2016 Dec;84:1051-1060. doi: 10.1016/j.biopha.2016.10.044. Epub 2016 Oct 22. Review. PubMed PMID: 27780133.

2: Sonawane RD, Deore VB, Patil SD, Patil CR, Surana SJ, Goyal RK. Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator. Physiol Behav. 2015 May 15;144:66-72. doi: 10.1016/j.physbeh.2015.02.036. Epub 2015 Feb 21. Review. PubMed PMID: 25708274.

3: Song WZ. [General survey on medicinal plants of the Gentianaceae family in China]. Zhong Yao Tong Bao. 1986 Nov;11(11):3-7. Review. Chinese. PubMed PMID: 2952322.

4: Anyanwu GO, Nisar-ur-Rehman, Onyeneke CE, Rauf K. Medicinal plants of the genus Anthocleista--A review of their ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2015 Dec 4;175:648-67. doi: 10.1016/j.jep.2015.09.032. Epub 2015 Nov 11. Review. PubMed PMID: 26432351.