WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530677
Description: NGP-555 is a gamma-secretase modulator with a selective mechanism to reduce Abeta 42 while raising shorter Abeta forms such as Abeta 37 and 38. NGP 555 is being developed as a preventative disease modifying therapy for Alzheimer's disease. NGP 555 shifts amyloid peptide production to the smaller, non-aggregating forms of amyloid. Our preclinical studies show beneficial effects on amyloid biomarkers, pathology, and cognition. NGP 555 has successfully completed chemistry, pharmacology, toxicity, metabolism, and safety studies.
MedKoo Cat#: 530677
Chemical Formula: C23H23FN4S
Exact Mass: 406.1627
Molecular Weight: 406.5234
Elemental Analysis: C, 67.96; H, 5.70; F, 4.67; N, 13.78; S, 7.89
Synonym: NGP-555; NGP 555; NGP555.
IUPAC/Chemical Name: N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine
InChi Key: WDEKUGNKKOGFOA-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23FN4S/c1-5-17-10-20(15(3)8-14(17)2)26-23-27-21(12-29-23)18-6-7-22(19(24)9-18)28-11-16(4)25-13-28/h6-13H,5H2,1-4H3,(H,26,27)
SMILES Code: FC1=CC(C2=CSC(NC3=CC(CC)=C(C)C=C3C)=N2)=CC=C1N4C=C(C)N=C4
1: Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. NGP 555, a
γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ(42,) in Cerebrospinal
Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
Alzheimers Dement (N Y). 2017 Jan;3(1):65-73. doi: 10.1016/j.trci.2016.09.003.
PubMed PMID: 28497107; PubMed Central PMCID: PMC5421551.
2: Burt J. American Chemical Society - 240th national meeting - chemistry for
preventing and combating disease: part 1. IDrugs. 2010 Oct;13(10):669-72. PubMed