NGP-555
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MedKoo CAT#: 530677

CAS#: 1304630-27-0

Description: NGP-555 is a gamma-secretase modulator with a selective mechanism to reduce Abeta 42 while raising shorter Abeta forms such as Abeta 37 and 38. NGP 555 is being developed as a preventative disease modifying therapy for Alzheimer's disease. NGP 555 shifts amyloid peptide production to the smaller, non-aggregating forms of amyloid. Our preclinical studies show beneficial effects on amyloid biomarkers, pathology, and cognition. NGP 555 has successfully completed chemistry, pharmacology, toxicity, metabolism, and safety studies.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 275 2 Weeks
5mg USD 555 2 Weeks
10mg USD 925 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

NGP-555, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530677
Name: NGP-555
CAS#: 1304630-27-0
Chemical Formula: C23H23FN4S
Exact Mass: 406.1627
Molecular Weight: 406.5234
Elemental Analysis: C, 67.96; H, 5.70; F, 4.67; N, 13.78; S, 7.89


Synonym: NGP-555; NGP 555; NGP555.

IUPAC/Chemical Name: N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

InChi Key: WDEKUGNKKOGFOA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23FN4S/c1-5-17-10-20(15(3)8-14(17)2)26-23-27-21(12-29-23)18-6-7-22(19(24)9-18)28-11-16(4)25-13-28/h6-13H,5H2,1-4H3,(H,26,27)

SMILES Code: FC1=CC(C2=CSC(NC3=CC(CC)=C(C)C=C3C)=N2)=CC=C1N4C=C(C)N=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. NGP 555, a
γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ(42,) in Cerebrospinal
Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
Alzheimers Dement (N Y). 2017 Jan;3(1):65-73. doi: 10.1016/j.trci.2016.09.003.
PubMed PMID: 28497107; PubMed Central PMCID: PMC5421551.

2: Burt J. American Chemical Society - 240th national meeting - chemistry for
preventing and combating disease: part 1. IDrugs. 2010 Oct;13(10):669-72. PubMed
PMID: 20878582.