NSC348884 | CAS#81624-55-7 | nucleophosmin inhibitor

NSC348884
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561190

CAS#: 81624-55-7

Description: NSC348884 is a nucleophosmin inhibitor. NSC348884 also disrupts oligomer formation and induces apoptosis in human cancer cells.

Chemical Structure

NSC348884

CAS# 81624-55-7

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561190
Name: NSC348884
CAS#: 81624-55-7
Chemical Formula: C38H40N10
Exact Mass: 636.34
Molecular Weight: 636.808
Elemental Analysis: C, 71.67; H, 6.33; N, 22.00

Price and Availability

Size	Price	Availability
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2150	2 Weeks
1g	USD 3250	2 Weeks
2g	USD 5450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NSC348884; NSC 348884; NSC-348884

IUPAC/Chemical Name: N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine

InChi Key: KZOLQEUQAFTQFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)

SMILES Code: CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines.
In vitro activity:	After HepG2 cells were treated by NSC348884 for 4 days, the effect of HepG2 cells on proliferation was measured by methyl thiazolyl tetrazolium (MTT) assay, the expression variation of nucleophosmin oligomer and monomer was measured using Western blotting, and cell apoptotic rate was detected by flow cytometry. The proliferation of HepG2 cells was remarkably inhibited by NSC348884 treatment when the drug concentration ranged from 1 micromol/L to 10 micromol/L (P < 0.05), with a 50% inhibiting concentration of 1.4 micromol/L. Reference: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Feb;34(1):58-61. https://pubmed.ncbi.nlm.nih.gov/22737721/
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	20.0	31.41
	DMF:PBS (pH 7.2) (1:2)	0.3	0.39
	DMSO	48.0	75.38
	Ethanol	50.5	79.30

Preparing Stock Solutions

The following data is based on the product molecular weight 636.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Zhang J, Zhao HL, He JF, Li HY. [Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Feb;34(1):58-61. Chinese. PMID: 22737721. 2. Qi W, Shakalya K, Stejskal A, Goldman A, Beeck S, Cooke L, Mahadevan D. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008 Jul 10;27(30):4210-20. doi: 10.1038/onc.2008.54. Epub 2008 Mar 17. PMID: 18345031.
In vitro protocol:	1. Zhang J, Zhao HL, He JF, Li HY. [Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Feb;34(1):58-61. Chinese. PMID: 22737721. 2. Qi W, Shakalya K, Stejskal A, Goldman A, Beeck S, Cooke L, Mahadevan D. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008 Jul 10;27(30):4210-20. doi: 10.1038/onc.2008.54. Epub 2008 Mar 17. PMID: 18345031.
In vivo protocol:	TBD

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1: Zhang J, Zhao HL, He JF, Li HY. [Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Feb;34(1):58-61. Chinese. PubMed PMID: 22737721.

2: Qi W, Shakalya K, Stejskal A, Goldman A, Beeck S, Cooke L, Mahadevan D. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008 Jul 10;27(30):4210-20. doi: 10.1038/onc.2008.54. Epub 2008 Mar 17. PubMed PMID: 18345031.

3: Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF. Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6. J Cell Biochem. 2017 May 17. doi: 10.1002/jcb.26135. [Epub ahead of print] PubMed PMID: 28513872.

4: Eichhorn T, Dolimbek BZ, Deeg K, Efferth T, Atassi MZ. Inhibition in vivo of the activity of botulinum neurotoxin A by small molecules selected by virtual screening. Toxicon. 2012 Nov;60(6):1180-90. doi: 10.1016/j.toxicon.2012.07.010. Epub 2012 Aug 14. PubMed PMID: 22960451.

5: Guo Y, Liu S, Wang P, Zhang H, Wang F, Bing L, Gao J, Yang J, Hao A. Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression. J Neurosci Res. 2014 Jun;92(6):751-60. PubMed PMID: 24829950.

6: Balusu R, Fiskus W, Rao R, Chong DG, Nalluri S, Mudunuru U, Ma H, Chen L, Venkannagari S, Ha K, Abhyankar S, Williams C, McGuirk J, Khoury HJ, Ustun C, Bhalla KN. Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1. Blood. 2011 Sep 15;118(11):3096-106. doi: 10.1182/blood-2010-09-309674. Epub 2011 Jun 30. PubMed PMID: 21719597.

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