WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561188
CAS#: 1594041-84-5
Description: WB403 is a TGR5 activator. WB403 significantly improves glucose tolerance and decreases fasting blood glucose, postprandial blood glucose and HbA1c in type 2 diabetic mice. WB403 also increases pancreatic β-cells and restores the normal distribution pattern of α-cell and β-cell in islets.
MedKoo Cat#: 561188
Name: WB403
CAS#: 1594041-84-5
Chemical Formula: C19H19BrN2OS
Exact Mass: 402.0401
Molecular Weight: 403.338
Elemental Analysis: C, 56.58; H, 4.75; Br, 19.81; N, 6.95; O, 3.97; S, 7.95
This product is not in stock, which may be available by custom synthesis.
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Synonym: WB403 ; WB-403; WB 403
IUPAC/Chemical Name: 4-(5-((4-Bromobenzyloxy)-methyl)-4-methylthiazol-2-yl)-2-ethylpyridine
InChi Key: NYKBJEUCSJOODJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19BrN2OS/c1-3-17-10-15(8-9-21-17)19-22-13(2)18(24-19)12-23-11-14-4-6-16(20)7-5-14/h4-10H,3,11-12H2,1-2H3
SMILES Code: CCC1=NC=CC(C2=NC(C)=C(COCC3=CC=C(Br)C=C3)S2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 403.338 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One. 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051. eCollection 2015. PubMed PMID: 26208278; PubMed Central PMCID: PMC4514850.
