WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561175
Description: MAC-0547630 potent and selective inhibitor of UppS. MAC-0547630 has no off-target effects on membrane potential.
MedKoo Cat#: 561175
Chemical Formula: C19H21FN4
Exact Mass: 324.175
Molecular Weight: 324.4034
Elemental Analysis: C, 70.35; H, 6.53; F, 5.86; N, 17.27
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: MAC-0547630; MAC0547630; MAC 0547630
IUPAC/Chemical Name: 7-Azepan-1-yl-3-(4-fluoro-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidine
InChi Key: MWBKFQJPGCZDRF-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21FN4/c1-14-12-18(23-10-4-2-3-5-11-23)24-19(22-14)17(13-21-24)15-6-8-16(20)9-7-15/h6-9,12-13H,2-5,10-11H2,1H3
SMILES Code: CC1=NC2=C(C3=CC=C(F)C=C3)C=NN2C(N4CCCCCC4)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 324.4034 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Czarny TL, Brown ED. A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase. ACS Infect Dis. 2016 Jul 8;2(7):489-99. doi: 10.1021/acsinfecdis.6b00044. Epub 2016 May 24. PubMed PMID: 27626101.