Alpha-Tocopherol phosphate

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MedKoo CAT#: 561141

CAS#: 38976-17-9

Description: Alpha-Tocopherol phosphate is a vascular endothelial growth factor (VEGF) expression inducer. Alpha-Tocopherol phosphate stimulates PI3Kγ activity by stimulating hTAP-mediated phosphatidylinositol exchange and presentation to the enzyme and/or dissociation of an inactive heterodimer.


Chemical Structure

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Alpha-Tocopherol phosphate
CAS# 38976-17-9

Theoretical Analysis

MedKoo Cat#: 561141
Name: Alpha-Tocopherol phosphate
CAS#: 38976-17-9
Chemical Formula: C29H51O5P
Exact Mass: 510.3474
Molecular Weight: 510.7
Elemental Analysis: C, 68.20; H, 10.07; O, 15.66; P, 6.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Alpha-Tocopherol phosphate; Alpha Tocopherol phosphate; Alphatocopherol phosphate; TocP; Vtamin E phosphate; αTP; α TP; α-TP

IUPAC/Chemical Name: [(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate

InChi Key: JUIUXBHZFNHITF-IEOSBIPESA-N

InChi Code: InChI=1S/C29H51O5P/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(34-35(30,31)32)23(5)24(6)28(26)33-29/h20-22H,9-19H2,1-8H3,(H2,30,31,32)/t21-,22-,29-/m1/s1

SMILES Code: O=P(O)(OC1=C(C)C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C2C(C)=C1C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 510.7 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zingg JM, Meydani M, Azzi A. alpha-Tocopheryl phosphate--an active lipid mediator? Mol Nutr Food Res. 2010 May;54(5):679-92. doi: 10.1002/mnfr.200900404. Review. PubMed PMID: 20169583.

2: Birringer M. Analysis of vitamin E metabolites in biological specimen. Mol Nutr Food Res. 2010 May;54(5):588-98. doi: 10.1002/mnfr.200900457. Review. PubMed PMID: 20169585.

3: Zingg JM, Meydani M, Azzi A. α-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis? Biofactors. 2012 Jan-Feb;38(1):24-33. doi: 10.1002/biof.198. Epub 2012 Jan 27. Review. PubMed PMID: 22281871.