WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561079

CAS#: 405165-77-7

Description: ISQ-1 HCl is an an isoquinolinone (IKur) blocker. ISQ-1 HCl has been investigated for treatment of atrial arrhythmia.

Chemical Structure

CAS# 405165-77-7

Theoretical Analysis

MedKoo Cat#: 561079
Name: ISQ-1 HCl
CAS#: 405165-77-7
Chemical Formula: C20H23ClN2O2
Exact Mass:
Molecular Weight: 358.87
Elemental Analysis: C, 66.94; H, 6.46; Cl, 9.88; N, 7.81; O, 8.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ISQ-1 HCl; ISQ1 HCl; ISQ 1 HCl; ISQ-1; ISQ1; ISQ 1

IUPAC/Chemical Name: 3-[(Dimethylamino)-methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one Hydrochloride


InChi Code: InChI=1S/C20H22N2O2.ClH/c1-21(2)13-18-19(14-8-6-5-7-9-14)17-12-15(24-4)10-11-16(17)20(23)22(18)3;/h5-12H,13H2,1-4H3;1H

SMILES Code: O=C1N(C)C(CN(C)C)=C(C2=CC=CC=C2)C3=C1C=CC(OC)=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 358.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Regan CP, Stump GL, Wallace AA, Anderson KD, McIntyre CJ, Liverton NJ, Lynch JJ Jr. In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate. J Cardiovasc Pharmacol. 2007 Apr;49(4):236-45. PubMed PMID: 17438409.

2: Regan CP, Kiss L, Stump GL, McIntyre CJ, Beshore DC, Liverton NJ, Dinsmore CJ, Lynch JJ Jr. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. J Pharmacol Exp Ther. 2008 Jan;324(1):322-30. Epub 2007 Oct 29. PubMed PMID: 17967939.