Isomaltitol
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MedKoo CAT#: 561057

CAS#: 534-73-6

Description: Isomaltitol, also known as Palatinit or Isomalt, is a sugar alcohol. Isomaltitol is commonly used as a sweetener in food products. There is some evidence that Isomaltitol could be used to aid mucus clearance in cystic fibrosis patients.

Chemical Structure

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Isomaltitol
CAS# 534-73-6
Instruction

Theoretical Analysis

MedKoo Cat#: 561057
Name: Isomaltitol
CAS#: 534-73-6
Chemical Formula: C12H24O11
Exact Mass: 344.13
Molecular Weight: 344.310
Elemental Analysis: C, 41.86; H, 7.03; O, 51.11

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 Weeks
1g USD 750 2 Weeks
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Related CAS #: 534-73-6 (Isomaltitol)   64519-82-0 (Palatinit)  

Synonym: Isomaltitol; Palatinit; Isomalt

IUPAC/Chemical Name: (2S,3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol

InChi Key: SERLAGPUMNYUCK-YJOKQAJESA-N

InChi Code: InChI=1S/C12H24O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1

SMILES Code: OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 344.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abe K, Kuroda A, Takeshita R. Engineering of Escherichia coli to facilitate efficient utilization of isomaltose and panose in industrial glucose feedstock. Appl Microbiol Biotechnol. 2017 Mar;101(5):2057-2066. doi: 10.1007/s00253-016-8037-z. Epub 2016 Dec 8. PubMed PMID: 27933453; PubMed Central PMCID: PMC5309279.

2: Schröder S, Kröger L, Mattes R, Thiem J. Transglycosylations employing recombinant α- and β-galactosidases and novel donor substrates. Carbohydr Res. 2015 Feb 11;403:157-66. doi: 10.1016/j.carres.2014.05.005. Epub 2014 May 20. PubMed PMID: 24909380.

3: Evaldsson C, Rydén I, Uppugunduri S. Isomaltitol exacerbates neutrophilia but reduces eosinophilia: new insights into the sephadex model of lung inflammation. Int Arch Allergy Immunol. 2011;154(4):286-94. doi: 10.1159/000321820. Epub 2010 Oct 20. PubMed PMID: 20962533.

4: Uppugunduri S, Gautam C. Effects of uridine, isomatitol and 4-thiouridine on in vitro cell adhesion and in vivo effects of 4-thiouridine in a lung inflammation model. Int Immunopharmacol. 2004 Sep;4(9):1241-8. PubMed PMID: 15251120.

5: Cataldi TR, Campa C, Casella IG, Bufo SA. Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection. J Agric Food Chem. 1999 Jan;47(1):157-63. PubMed PMID: 10563865.

6: Smits-Van Prooije AE, De Groot AP, Dreef-Van der Meulen HC, Sinkeldam EJ. Chronic toxicity and carcinogenicity study of isomalt in rats and mice. Food Chem Toxicol. 1990 Apr;28(4):243-51. PubMed PMID: 2358250.

7: Rosiers C, Verwaerde F, Dupas H, Bouquelet S. New approach to the metabolism of hydrogenated starch hydrolysate: hydrolysis by the maltase/glucoamylase complex of the rat intestinal mucosa. Ann Nutr Metab. 1985;29(2):76-82. PubMed PMID: 3922278.

8: Ziesenitz SC. Bioavailability of glucose from Palatinit. Z Ernahrungswiss. 1983 Sep;22(3):185-94. PubMed PMID: 6417920.

9: Siebert G, Grupp U, Heinkel K. Studies on isomaltitol. Nutr Metab. 1975;18 Suppl 1:191-6. PubMed PMID: 1165864.

10: Musch K, Siebert G, Schiweck H, Steinle G. [Nutritional physiology of isomaltitol in the rat]. Z Ernahrungswiss Suppl. 1973;15:3-16. German. PubMed PMID: 4518248.

11: Gehring F. [Formation of acids by cariogenically important streptococci from sugars and sugar alcohols with special reference to isomaltitol and isomaltulose]. Z Ernahrungswiss Suppl. 1973;15:16-27. German. PubMed PMID: 4518246.