CBIP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561054

CAS#: Unknown

Description: CBIP is a small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC). CBIP possesses low micromolar activity against BoNT/A.

Chemical Structure

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CBIP
CAS# Unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 561054
Name: CBIP
CAS#: Unknown
Chemical Formula: C18H17ClN2O2
Exact Mass: 328.10
Molecular Weight: 328.800
Elemental Analysis: C, 65.75; H, 5.21; Cl, 10.78; N, 8.52; O, 9.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CBIP

IUPAC/Chemical Name: 5-(1-Butyl-4-chloro-1H-indol-2-yl)picolinic acid

InChi Key: WBHKRGOPCYOGDO-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClN2O2/c1-2-3-9-21-16-6-4-5-14(19)13(16)10-17(21)12-7-8-15(18(22)23)20-11-12/h4-8,10-11H,2-3,9H2,1H3,(H,22,23)

SMILES Code: O=C(O)C1=NC=C(C(N2CCCC)=CC3=C2C=CC=C3Cl)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bremer PT, Xue S, Janda KD. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain. Chem Commun (Camb). 2016 Oct 13;52(84):12521-12524. PubMed PMID: 27722252; PubMed Central PMCID: PMC5085802.

2: Wu YC, Hsieh WS, Hsu CH, Chang JH, Chou HC, Hsu HC, Chiu NC, Lee WT, Chen WJ, Ho YW, Jeng SF. Intervention effects on emotion regulation in preterm infants with very low birth weight: A randomize controlled trial. Res Dev Disabil. 2016 Jan;48:1-12. doi: 10.1016/j.ridd.2015.10.016. Epub 2015 Oct 31. PubMed PMID: 26524725.

3: Wu YC, Leng CH, Hsieh WS, Hsu CH, Chen WJ, Gau SS, Chiu NC, Yang MC, Li-Jung Fang, Hsu HC, Yu YT, Wu YT, Chen LC, Jeng SF. A randomized controlled trial of clinic-based and home-based interventions in comparison with usual care for preterm infants: effects and mediators. Res Dev Disabil. 2014 Oct;35(10):2384-93. doi: 10.1016/j.ridd.2014.06.009. Epub 2014 Jun 26. PubMed PMID: 24973546.

4: Fresquet V, Williams L, Raushel FM. Partial randomization of the four sequential amidation reactions catalyzed by cobyric acid synthetase with a single point mutation. Biochemistry. 2007 Dec 11;46(49):13983-93. Epub 2007 Nov 15. PubMed PMID: 18001139; PubMed Central PMCID: PMC2518967.

5: Roessner CA, Williams HJ, Scott AI. Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin. J Biol Chem. 2005 Apr 29;280(17):16748-53. Epub 2005 Feb 28. PubMed PMID: 15741157.

6: Woodson JD, Zayas CL, Escalante-Semerena JC. A new pathway for salvaging the coenzyme B12 precursor cobinamide in archaea requires cobinamide-phosphate synthase (CbiB) enzyme activity. J Bacteriol. 2003 Dec;185(24):7193-201. PubMed PMID: 14645280; PubMed Central PMCID: PMC296239.

7: Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ. The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway. J Biol Chem. 2000 Dec 22;275(51):40316-23. PubMed PMID: 11007789.

8: Raux E, Lanois A, Rambach A, Warren MJ, Thermes C. Cobalamin (vitamin B12) biosynthesis: functional characterization of the Bacillus megaterium cbi genes required to convert uroporphyrinogen III into cobyrinic acid a,c-diamide. Biochem J. 1998 Oct 1;335 ( Pt 1):167-73. PubMed PMID: 9742226; PubMed Central PMCID: PMC1219765.