MS-1020
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561038

CAS#: 1255516-86-9

Description: MS-1020 is a JAK3 and STAT3 inhibitor. MS-1020 potently inhibits persistently-active STAT3 in a cell type-specific manner. MS-1020 selectively blocks constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling.


Chemical Structure

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MS-1020
CAS# 1255516-86-9

Theoretical Analysis

MedKoo Cat#: 561038
Name: MS-1020
CAS#: 1255516-86-9
Chemical Formula: C21H18N2O3
Exact Mass: 346.1317
Molecular Weight: 346.386
Elemental Analysis: C, 72.82; H, 5.24; N, 8.09; O, 13.86

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
25.0mg USD 620.0 2 Weeks
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Synonym: MS-1020; MS 1020; MS1020

IUPAC/Chemical Name: 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

InChi Key: KHJNISGKGIHTMY-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18N2O3/c24-15-6-8-19-18(11-15)14(12-23-19)9-10-22-21(26)17-7-5-13-3-1-2-4-16(13)20(17)25/h1-8,11-12,23-25H,9-10H2,(H,22,26)

SMILES Code: O=C(C1=CC=C2C=CC=CC2=C1O)NCCC3=CNC4=C3C=C(O)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 346.386 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kim BH, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148(1):132-43. doi: 10.1111/j.1365-2141.2009.07925.x. Epub 2009 Sep 29. PubMed PMID: 19793252; PubMed Central PMCID: PMC3034357.

2: Sinclair CT, Kalender-Rich JL, Griebling TL, Porter-Williamson K. Palliative Care of Urologic Patients at End of Life. Clin Geriatr Med. 2015 Nov;31(4):667-78. doi: 10.1016/j.cger.2015.07.002. Review. PubMed PMID: 26476123.

3: Lemon RN, Mantel GW. The influence of changes in discharge frequency of corticospinal neurones on hand muscles in the monkey. J Physiol. 1989 Jun;413:351-78. PubMed PMID: 2600855; PubMed Central PMCID: PMC1189105.

4: Carmody J, Pawlak M, Messlinger K. Lack of a role for substance P in the control of dural arterial flow. Exp Brain Res. 1996 Oct;111(3):424-8. PubMed PMID: 8911936.

5: Buljubasich R, Ventura S. Adenosine 5'-triphosphate and noradrenaline are excitatory cotransmitters to the fibromuscular stroma of the guinea pig prostate gland. Eur J Pharmacol. 2004 Sep 24;499(3):335-44. PubMed PMID: 15381056.

6: Olschewski A, Bräu ME, Hempelmann G, Vogel W, Safronov BV. Differential block of fast and slow inactivating tetrodotoxin-sensitive sodium channels by droperidol in spinal dorsal horn neurons. Anesthesiology. 2000 Jun;92(6):1667-76. PubMed PMID: 10839918.

7: Kurosawa M, Messlinger K, Pawlak M, Schmidt RF. Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: mediation by calcitonin gene-related peptide. Br J Pharmacol. 1995 Apr;114(7):1397-402. PubMed PMID: 7606344; PubMed Central PMCID: PMC1510285.

8: Armour JA, Janes RD. Neuronal activity recorded extracellularly from in situ canine mediastinal ganglia. Can J Physiol Pharmacol. 1988 Feb;66(2):119-27. PubMed PMID: 3370543.

9: Brock JW, Joshua IG. Neural release of substance P causes dilation of arterioles in rat striated muscle. Regul Pept. 1993 Jan 22;43(1-2):65-71. PubMed PMID: 7678938.

MS-1020

5.0mg / USD 250.0