MDK-6983

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561022

CAS#: 1227476-98-3

Description: MDK-6983, also known as Autophagy inhibitor 6k, is a autophagy inhibitor. MDK-6983 has CAS#1227476-98-3. The last 4 digital is used in its name. MDK-6983 disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adhesion, motility, proliferation, vesicular transport, and autophagic flux. Inhibition of autophagy by MDK-6983 increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib.


Chemical Structure

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MDK-6983
CAS# 1227476-98-3

Theoretical Analysis

MedKoo Cat#: 561022
Name: MDK-6983
CAS#: 1227476-98-3
Chemical Formula: C22H18Cl2N2O3
Exact Mass: 428.07
Molecular Weight: 429.297
Elemental Analysis: C, 61.55; H, 4.23; Cl, 16.52; N, 6.53; O, 11.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Autophagy inhibitor 6k; Compound 6k; MDK-6983; MDK 6983; MDK6983.

IUPAC/Chemical Name: N-((R)-1-(4-Chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide

InChi Key: VDXPOMCEKWAGSX-LJQANCHMSA-N

InChi Code: InChI=1S/C22H18Cl2N2O3/c23-15-6-9-17(10-7-15)25-22(29)19(12-14-4-2-1-3-5-14)26-21(28)18-13-16(24)8-11-20(18)27/h1-11,13,19,27H,12H2,(H,25,29)(H,26,28)/t19-/m1/s1

SMILES Code: O=C(N[C@@H](C(NC1=CC=C(Cl)C=C1)=O)CC2=CC=CC=C2)C3=CC(Cl)=CC=C3O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Páchniková G, Uldrijan S, Imramovský A, Kryštof V, Slaninová I. Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux. Toxicol In Vitro. 2016 Dec;37:70-78. doi: 10.1016/j.tiv.2016.09.006. Epub 2016 Sep 7. PubMed PMID: 27612957.