WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561019

CAS#: 1984862-48-7

Description: OABK is a small molecule switch that can be used to control protein activity. Genetic encoding of OABK using a pyrrolysyl tRNA synthetase/tRNACUA pair in mammalian cells enables the site-specific introduction of a small molecule-removable protecting group into the protein of interest. A phosphine-mediated Staudinger reduction is used to re-activate protein function.

Chemical Structure

CAS# 1984862-48-7

Theoretical Analysis

MedKoo Cat#: 561019
Name: OABK
CAS#: 1984862-48-7
Chemical Formula: C14H20ClN5O4
Exact Mass:
Molecular Weight: 357.795
Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89Chemical Formula: C14H20ClN5O4 Exact Mass: 357.1204 Molecular Weight: 357.7950 Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: OABK; ortho-azidobenzyloxycarbonyl-L-lysine hydrochloride

IUPAC/Chemical Name: N6-(((4-Azidobenzyl)oxy)carbonyl)-L-lysine hydrochloride


InChi Code: InChI=1S/C14H19N5O4.ClH/c15-12(13(20)21)3-1-2-8-17-14(22)23-9-10-4-6-11(7-5-10)18-19-16;/h4-7,12H,1-3,8-9,15H2,(H,17,22)(H,20,21);1H/t12-;/m0./s1

SMILES Code: N[C@@H](CCCCNC(OCC1=CC=C(N=[N+]=[N-])C=C1)=O)C(O)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 357.795 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Small Molecule Control of Protein Function through Staudinger Reduction Ji Luo, Qingyang Liu, Kunihiko Morihiro, Alexander Deiters Nat Chem. Author manuscript; available in PMC 2017 Jan 25.Published in final edited form as: Nat Chem. 2016 Nov; 8(11): 1027–1034. Published online 2016 Jul 25. doi: 10.1038/nchem.2573 PMCID: PMC5119652

2: Approximate steady-state properties of lattices of interacting three-state enzyme molecules: a novel phase transition. T L Hill, L Stein Proc Natl Acad Sci U S A. 1979 Mar; 76(3): 1014–1017. PMCID: PMC383177