Sulforaphene
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MedKoo CAT#: 561018

CAS#: 592-95-0

Description: Sulforaphene efficiently decreased the viability of breast cancer cells, while normal cells (MCF10A) were less sensitive to the analyzed isothiocyanate. Sulforaphene induced G2/M cell cycle arrest, as well as disturbed cytoskeletal organization and reduced clonogenic potential of the cancer cells. Sulforaphene induced apoptosis in a concentration-dependent manner which was associated with the oxidative stress, mitochondria dysfunction, increased Bax:Bcl2 ratio and ADRP levels.

Chemical Structure

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Sulforaphene
CAS# 592-95-0
Instruction

Theoretical Analysis

MedKoo Cat#: 561018
Name: Sulforaphene
CAS#: 592-95-0
Chemical Formula: C6H9NOS2
Exact Mass: 175.01
Molecular Weight: 175.260
Elemental Analysis: C, 41.12; H, 5.18; N, 7.99; O, 9.13; S, 36.58

Price and Availability

Size Price Availability Quantity
1mg USD 195
5mg USD 385
10mg USD 475
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Synonym: Sulforaphene; Raphanin; Sulforaphen; Sulphoraphen

IUPAC/Chemical Name: 4-Isothiocyanato-1-(methylsulfinyl)-1-butene

InChi Key: QKGJFQMGPDVOQE-HWKANZROSA-N

InChi Code: InChI=1S/C6H9NOS2/c1-10(8)5-3-2-4-7-6-9/h3,5H,2,4H2,1H3/b5-3+

SMILES Code: O=S(/C=C/CCN=C=S)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 175.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lee JG, Lim S, Kim J, Lee EJ. The mechanism of deterioration of the glucosinolate-myrosynase system in radish roots during cold storage after harvest. Food Chem. 2017 Oct 15;233:60-68. doi: 10.1016/j.foodchem.2017.04.104. Epub 2017 Apr 19. PubMed PMID: 28530612.

2: Pawlik A, Wała M, Hać A, Felczykowska A, Herman-Antosiewicz A. Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells. Phytomedicine. 2017 Jun 15;29:1-10. doi: 10.1016/j.phymed.2017.03.007. Epub 2017 Apr 4. PubMed PMID: 28515021.

3: Ren K, Li Z, Li Y, Zhang W, Han X. Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. J Biochem Mol Toxicol. 2017 Mar 27. doi: 10.1002/jbt.21917. [Epub ahead of print] PubMed PMID: 28346727.

4: Takagi T, Inoue H, Takahashi N, Katsumata-Tsuboi R, Uehara M. Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2. Biosci Biotechnol Biochem. 2017 Jun;81(6):1220-1223. doi: 10.1080/09168451.2017.1281729. Epub 2017 Jan 30. PubMed PMID: 28136694.

5: Yang M, Wang H, Zhou M, Liu W, Kuang P, Liang H, Yuan Q. The natural compound sulforaphene, as a novel anticancer reagent, targeting PI3K-AKT signaling pathway in lung cancer. Oncotarget. 2016 Nov 22;7(47):76656-76666. doi: 10.18632/oncotarget.12307. PubMed PMID: 27765931; PubMed Central PMCID: PMC5363538.

6: Ko MO, Kim MB, Lim SB. Relationship between Chemical Structure and Antimicrobial Activities of Isothiocyanates from Cruciferous Vegetables against Oral Pathogens. J Microbiol Biotechnol. 2016 Dec 28;26(12):2036-2042. doi: 10.4014/jmb.1606.06008. PubMed PMID: 27586534.

7: Biswas R, Mondal A, Chatterjee S, Ahn JC. Evaluation of synergistic effects of sulforaphene with photodynamic therapy in human cervical cancer cell line. Lasers Med Sci. 2016 Nov;31(8):1675-1682. Epub 2016 Aug 3. PubMed PMID: 27485253.

8: Chatterjee S, Rhee YH, Ahn JC. Sulforaphene-Carboplatin Combination Synergistically Enhances Apoptosis by Disruption of Mitochondrial Membrane Potential and Cell Cycle Arrest in Human Non-Small Cell Lung Carcinoma. J Med Food. 2016 Sep;19(9):860-9. doi: 10.1089/jmf.2016.3675. Epub 2016 Jul 28. PubMed PMID: 27467015.

9: Yang M, Teng W, Qu Y, Wang H, Yuan Q. Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1. Breast Cancer Res Treat. 2016 Jul;158(2):277-86. doi: 10.1007/s10549-016-3888-7. Epub 2016 Jul 4. PubMed PMID: 27377973.

10: Bao C, Kim MC, Chen J, Song J, Ko HW, Lee HJ. Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling. J Agric Food Chem. 2016 Jul 13;64(27):5515-24. doi: 10.1021/acs.jafc.6b02195. Epub 2016 Jun 29. PubMed PMID: 27327035.