AX15836
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561008

CAS#: 2035509-96-5

Description: AX15836 is a highly potent and selective ERK5 inhibitor.

Chemical Structure

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AX15836
CAS# 2035509-96-5
Instruction

Theoretical Analysis

MedKoo Cat#: 561008
Name: AX15836
CAS#: 2035509-96-5
Chemical Formula: C32H40N8O5S
Exact Mass: 648.28
Molecular Weight: 648.780
Elemental Analysis: C, 59.24; H, 6.21; N, 17.27; O, 12.33; S, 4.94

Price and Availability

Size Price Availability Quantity
10mg USD 650 2 Weeks
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Synonym: AX15836; AX 15836; AX-15836

IUPAC/Chemical Name: 2-(2-Ethoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5-methyl-11-(methylsulfonyl)-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one

InChi Key: HTFNVAVTYILUCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C32H40N8O5S/c1-5-45-28-20-22(30(41)39-14-12-23(13-15-39)38-18-16-36(2)17-19-38)10-11-25(28)34-32-33-21-27-29(35-32)40(46(4,43)44)26-9-7-6-8-24(26)31(42)37(27)3/h6-11,20-21,23H,5,12-19H2,1-4H3,(H,33,34,35)

SMILES Code: O=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 648.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Biological Sciences - Cell Biology:
ERK5 kinase activity is dispensable for cellular immune response and proliferation
Emme C. K. Lin, Christopher M. Amantea, Tyzoon K. Nomanbhoy, Helge Weissig, Junichi Ishiyama, Yi Hu, Shyama Sidique, Bei Li, John W. Kozarich, and Jonathan S. Rosenblum
PNAS 2016 ; published ahead of print September 27, 2016, doi:10.1073/pnas.1609019113