Ginsenoside Rh1
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MedKoo CAT#: 540175

CAS#: 63223-86-9

Description: Ginsenoside Rh1 is found in the species of Panax. It exhibits various biological activities, including enhancing memory and learning, decreasing adipocyte differentiation, inhibiting migration and invasion of hepatocellular carcinoma cells, and suppressing mast cell degranulation and anaphylaxis.

Chemical Structure

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Ginsenoside Rh1
CAS# 63223-86-9
Instruction

Theoretical Analysis

MedKoo Cat#: 540175
Name: Ginsenoside Rh1
CAS#: 63223-86-9
Chemical Formula: C36H62O9
Exact Mass: 638.44
Molecular Weight: 638.883
Elemental Analysis: C, 67.68; H, 9.78; O, 22.54

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 Weeks
10mg USD 550 2 Weeks
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Synonym: ginsenoside Rh1; HY-N0604; HYN0604; HY N0604; CS-3834; CS3834; CS 3834

IUPAC/Chemical Name: (2R,3R,4S,5S,6R)-2-(((3S,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: RAQNTCRNSXYLAH-OUEXKMQZSA-N

InChi Code: InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30?,31+,33+,34+,35+,36-/m0/s1

SMILES Code: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1O[C@@H]2C3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]4([H])C[C@@H](O)[C@]5([H])[C@@H]([C@@](C)(O)CC/C=C(C)\C)CC[C@](C)5[C@@](C)4C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 638.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hou J, Xue J, Lee M, Yu J, Sung C. Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. Int J Mol Med. 2014 Jan;33(1):234-40. doi: 10.3892/ijmm.2013.1552. Epub 2013 Nov 8. PubMed PMID: 24212564.

2: Feng Y, Wang C, Cheng S, Wang X, Meng X, Li L, Du J, Liu Q, Guo Y, Meng Y, Cheng B, Ling C. Ginsenoside Rh1 Improves the Effect of Dexamethasone on Autoantibodies Production and Lymphoproliferation in MRL/lpr Mice. Evid Based Complement Alternat Med. 2015;2015:727650. doi: 10.1155/2015/727650. Epub 2015 Mar 31. PubMed PMID: 25918545; PubMed Central PMCID: PMC4397023.

3: Li J, Du J, Liu D, Cheng B, Fang F, Weng L, Wang C, Ling C. Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance. Arthritis Res Ther. 2014 May 1;16(3):R106. doi: 10.1186/ar4556. PubMed PMID: 24887434; PubMed Central PMCID: PMC4060561.

4: Luo SL, Dang LZ, Zhang KQ, Liang LM, Li GH. Cloning and heterologous expression of UDP-glycosyltransferase genes from Bacillus subtilis and its application in the glycosylation of ginsenoside Rh1. Lett Appl Microbiol. 2015 Jan;60(1):72-8. doi: 10.1111/lam.12339. Epub 2014 Nov 16. PubMed PMID: 25327709.

5: Gu W, Kim KA, Kim DH. Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. Biol Pharm Bull. 2013;36(1):102-7. PubMed PMID: 23302642.

6: Lee SY, Jeong JJ, Eun SH, Kim DH. Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis. Eur J Pharmacol. 2015 Sep 5;762:333-43. doi: 10.1016/j.ejphar.2015.06.011. Epub 2015 Jun 6. PubMed PMID: 26054809.

7: Siddiqi MH, Siddiqi MZ, Ahn S, Kim YJ, Yang DC. Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway. J Pharm Pharmacol. 2014 Dec;66(12):1763-73. doi: 10.1111/jphp.12306. Epub 2014 Aug 24. PubMed PMID: 25154440.

8: Jeong JJ, Kim B, Kim DH. Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1. Biol Pharm Bull. 2013;36(7):1088-94. PubMed PMID: 23811558.

9: Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z. Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts. Mol Plant. 2015 Sep;8(9):1412-24. doi: 10.1016/j.molp.2015.05.010. Epub 2015 May 30. PubMed PMID: 26032089.

10: Jung JS, Ahn JH, Le TK, Kim DH, Kim HS. Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells. Neurochem Int. 2013 Aug;63(2):80-6. doi: 10.1016/j.neuint.2013.05.002. Epub 2013 May 15. PubMed PMID: 23684955.

11: Quan LH, Min JW, Sathiyamoorthy S, Yang DU, Kim YJ, Yang DC. Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase. Biotechnol Lett. 2012 May;34(5):913-7. doi: 10.1007/s10529-012-0849-z. Epub 2012 Jan 20. PubMed PMID: 22261865.

12: Gai Y, Ma Z, Yu X, Qu S, Sui D. Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Toxicol Mech Methods. 2012 Oct;22(8):584-91. doi: 10.3109/15376516.2012.702798. Epub 2012 Jul 18. PubMed PMID: 22694660.

13: Yoon JH, Choi YJ, Lee SG. Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. Eur J Pharmacol. 2012 Mar 15;679(1-3):24-33. doi: 10.1016/j.ejphar.2012.01.020. Epub 2012 Jan 31. PubMed PMID: 22314224.

14: Choi YJ, Yoon JH, Cha SW, Lee SG. Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. Fitoterapia. 2011 Sep;82(6):911-9. doi: 10.1016/j.fitote.2011.05.005. Epub 2011 May 14. PubMed PMID: 21605636.

15: Zheng H, Jeong Y, Song J, Ji GE. Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice. Int Immunopharmacol. 2011 Apr;11(4):511-8. doi: 10.1016/j.intimp.2010.12.022. Epub 2011 Jan 14. PubMed PMID: 21238621.

16: Qu H, Wang Y, Shan W, Zhang Y, Feng H, Sai J, Wang Q, Zhao Y. Development of ELISA for detection of Rh1 and Rg2 and potential method of immunoaffinity chromatography for separation of epimers. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:197-205. doi: 10.1016/j.jchromb.2015.01.037. Epub 2015 Feb 3. PubMed PMID: 25706410.

17: Hou J, Li W, Zheng Y. [Determination and enzymolysis preparation of ginsenoside Rh1]. Zhongguo Zhong Yao Za Zhi. 2009 Dec;34(23):3030-3. Chinese. PubMed PMID: 20222417.

18: Jung JS, Lee SY, Kim DH, Kim HS. Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling. Biomol Ther (Seoul). 2016 Jan;24(1):33-9. doi: 10.4062/biomolther.2015.129. Epub 2016 Jan 1. PubMed PMID: 26759699; PubMed Central PMCID: PMC4703350.

19: Wang YZ, Chen J, Chu SF, Wang YS, Wang XY, Chen NH, Zhang JT. Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. J Pharmacol Sci. 2009 Apr;109(4):504-10. PubMed PMID: 19372633.

20: Jung JS, Kim DH, Kim HS. Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem Biophys Res Commun. 2010 Jun 25;397(2):323-8. doi: 10.1016/j.bbrc.2010.05.117. Epub 2010 May 27. PubMed PMID: 20510882.