Ginsenoside Rg2
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MedKoo CAT#: 540172

CAS#: 52286-74-5

Description: Ginsenoside Rg2 is found in species of Panax. It inhibits LPS-stimulated production of VCAM-1 and ICAM-1, suppresses hepatic glucose production, and improves neural performance and cognition in animal models of vascular dementia.

Chemical Structure

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Ginsenoside Rg2
CAS# 52286-74-5
Instruction

Theoretical Analysis

MedKoo Cat#: 540172
Name: Ginsenoside Rg2
CAS#: 52286-74-5
Chemical Formula: C42H72O13
Exact Mass: 784.50
Molecular Weight: 785.020
Elemental Analysis: C, 64.26; H, 9.25; O, 26.49

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10mg USD 420
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Synonym: Ginsenoside RG2; Prosapogenin C2

IUPAC/Chemical Name: (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((6R,8R,9R,10R,12S,13R,14R,17S)-3,12-dihydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

InChi Key: AGBCLJAHARWNLA-QWLKVGLZSA-N

InChi Code: InChI=1S/C42H72O13/c1-20(2)11-10-14-42(9,51)22-12-16-40(7)28(22)23(44)17-26-39(6)15-13-27(45)38(4,5)35(39)24(18-41(26,40)8)53-37-34(32(49)30(47)25(19-43)54-37)55-36-33(50)31(48)29(46)21(3)52-36/h11,21-37,43-51H,10,12-19H2,1-9H3/t21-,22-,23-,24+,25+,26+,27?,28-,29-,30+,31+,32-,33+,34+,35?,36-,37+,39+,40+,41+,42-/m0/s1

SMILES Code: O[C@@H]([C@@H]([C@@H](CO)O1)O)[C@@H](O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)[C@@H]1O[C@H]3C4C(C)(C)C(O)CC[C@]4(C)[C@@]5([H])C[C@H](O)[C@]6([H])[C@@H]([C@@](C)(O)CC/C=C(C)\C)CC[C@](C)6[C@@](C)5C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 785.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fu W, Sui D, Yu X, Gou D, Zhou Y, Xu H. Protective effects of ginsenoside Rg2 against H2O2-induced injury and apoptosis in H9c2 cells. Int J Clin Exp Med. 2015 Nov 15;8(11):19938-47. eCollection 2015. PubMed PMID: 26884906; PubMed Central PMCID: PMC4723751.

2: Du J, Cui CH, Park SC, Kim JK, Yu HS, Jin FX, Sun C, Kim SC, Im WT. Identification and characterization of a ginsenoside-transforming β-glucosidase from Pseudonocardia sp. Gsoil 1536 and its application for enhanced production of minor ginsenoside Rg2(S). PLoS One. 2014 Jun 9;9(6):e96914. doi: 10.1371/journal.pone.0096914. eCollection 2014. PubMed PMID: 24911166; PubMed Central PMCID: PMC4049585.

3: Kang HJ, Huang YH, Lim HW, Shin D, Jang K, Lee Y, Kim K, Lim CJ. Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes. J Photochem Photobiol B. 2016 Dec;165:232-239. doi: 10.1016/j.jphotobiol.2016.10.034. Epub 2016 Oct 29. PubMed PMID: 27816645.

4: Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013 Apr;17(2):133-7. doi: 10.4196/kjpp.2013.17.2.133. Epub 2013 Apr 10. PubMed PMID: 23626475; PubMed Central PMCID: PMC3634090.

5: Quan LH, Min JW, Sathiyamoorthy S, Yang DU, Kim YJ, Yang DC. Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase. Biotechnol Lett. 2012 May;34(5):913-7. doi: 10.1007/s10529-012-0849-z. Epub 2012 Jan 20. PubMed PMID: 22261865.

6: Li CT, Wang HB, Xu BJ. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. Pharm Biol. 2013 Aug;51(8):1077-80. doi: 10.3109/13880209.2013.775164. Epub 2013 Jun 6. PubMed PMID: 23742679.

7: Pi MS, Ru Q, Gong XK, Wu RH, Tian X, Xiong Qi, Li CY. [Effect of Ginsenoside Rg2 and Its Stereoisomers on Oxygen-Glucose Deprivation and Reperfusion Induced Cortical Neuronal Injury Model]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Mar;36(3):333-8. Chinese. PubMed PMID: 27236892.

8: Yuan HD, Kim DY, Quan HY, Kim SJ, Jung MS, Chung SH. Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells. Chem Biol Interact. 2012 Jan 5;195(1):35-42. doi: 10.1016/j.cbi.2011.10.006. Epub 2011 Oct 31. PubMed PMID: 22062806.

9: Qu H, Wang Y, Shan W, Zhang Y, Feng H, Sai J, Wang Q, Zhao Y. Development of ELISA for detection of Rh1 and Rg2 and potential method of immunoaffinity chromatography for separation of epimers. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:197-205. doi: 10.1016/j.jchromb.2015.01.037. Epub 2015 Feb 3. PubMed PMID: 25706410.

10: Tian JM, Li H, Ye JM, Guo WF, Li LY, Wang LP. [Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats]. Zhongguo Zhong Yao Za Zhi. 2003 Dec;28(12):1191-2. Chinese. PubMed PMID: 15617510.

11: Yang X, Gui F, Song Y, Zhang W, Tian J, Li L. [Study on excretion of ginsenoside Rg2 in rats]. Zhongguo Zhong Yao Za Zhi. 2009 May;34(10):1281-4. Chinese. PubMed PMID: 19673396.

12: Li N, Liu B, Dluzen DE, Jin Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J Ethnopharmacol. 2007 May 22;111(3):458-63. Epub 2006 Dec 20. PubMed PMID: 17257792.

13: Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 2008 Feb 12;115(3):441-8. Epub 2007 Oct 25. PubMed PMID: 18083315.

14: Song JH, Choi HJ, Song HH, Hong EH, Lee BR, Oh SR, Choi K, Yeo SG, Lee YP, Cho S, Ko HJ. Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3. J Ginseng Res. 2014 Jul;38(3):173-9. doi: 10.1016/j.jgr.2014.04.003. Epub 2014 Apr 29. PubMed PMID: 25378991; PubMed Central PMCID: PMC4213867.

15: Ha SE, Shin DH, Kim HD, Shim SM, Kim HS, Kim BH, Lee JS, Park JK. Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Jul;382(1):89-101. doi: 10.1007/s00210-010-0522-9. Epub 2010 May 28. PubMed PMID: 20508917.

16: Choi S, Lee JH, Oh S, Rhim H, Lee SM, Nah SY. Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells. 2003 Feb 28;15(1):108-13. PubMed PMID: 12661769.

17: Yoon SR, Nah JJ, Kim SK, Kim SC, Nam KY, Jung DW, Nah SY. Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay. Chem Pharm Bull (Tokyo). 1998 Jul;46(7):1144-7. PubMed PMID: 9692222.

18: Wang YG, Liu HS, Zhang XX, Xiao Y, Lu BB, Ma ZC, Liang QD, Tang XL, Xiao CR, Tan HL, Zhang BL, Gao Y. [Screening of pregnane X receptor activation from ginsenosides]. Yao Xue Xue Bao. 2013 Jan;48(1):144-8. Chinese. PubMed PMID: 23600156.

19: Kim U, Park MH, Kim DH, Yoo HH. Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration. Food Chem. 2013 Feb 15;136(3-4):1364-9. doi: 10.1016/j.foodchem.2012.09.050. Epub 2012 Sep 21. PubMed PMID: 23194536.

20: Kaku T, Kawashima Y. Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report. Arzneimittelforschung. 1980;30(6):936-43. PubMed PMID: 7191267.