MPX-007

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530664

CAS#: 1688685-29-1

Description: MPX-007 is a potent NMDA inhibitor. MPX-007 inhibit GluN2A-containing NMDA receptors expressed in HEK cells with IC50s of 27 nM. MPX-007 offer highly selective pharmacological tools to probe GluN2A physiology and involvement in neuropsychiatric and developmental disorders.


Chemical Structure

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MPX-007
CAS# 1688685-29-1

Theoretical Analysis

MedKoo Cat#: 530664
Name: MPX-007
CAS#: 1688685-29-1
Chemical Formula: C18H17F2N5O3S2
Exact Mass: 453.07
Molecular Weight: 453.483
Elemental Analysis: C, 47.68; H, 3.78; F, 8.38; N, 15.44; O, 10.58; S, 14.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MPX-007; MPX 007; MPX007.

IUPAC/Chemical Name: 5-(((3,4-difluorophenyl)sulfonamido)methyl)-6-methyl-N-((2-methylthiazol-5-yl)methyl)pyrazine-2-carboxamide

InChi Key: GZXSPNTWOSSNMG-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17F2N5O3S2/c1-10-16(9-24-30(27,28)13-3-4-14(19)15(20)5-13)22-8-17(25-10)18(26)23-7-12-6-21-11(2)29-12/h3-6,8,24H,7,9H2,1-2H3,(H,23,26)

SMILES Code: O=C(C1=NC(C)=C(CNS(=O)(C2=CC=C(F)C(F)=C2)=O)N=C1)NCC3=CN=C(C)S3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: GluN2A is the most abundant of the GluN2 NMDA receptor subunits in the mammalian CNS. Physiological and genetic evidence implicate GluN2A-containing receptors in susceptibility to autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders such as Rett Syndrome.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 453.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: PLOS ONE Staff. Correction: MPX-004 and MPX-007: New Pharmacological Tools to
Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One.
2016 Mar 8;11(3):e0151452. doi: 10.1371/journal.pone.0151452. eCollection 2016.
PubMed PMID: 26954554; PubMed Central PMCID: PMC4783002.


2: Volkmann RA, Fanger CM, Anderson DR, Sirivolu VR, Paschetto K, Gordon E,
Virginio C, Gleyzes M, Buisson B, Steidl E, Mierau SB, Fagiolini M, Menniti FS.
MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA
Receptors Containing the GluN2A Subunit. PLoS One. 2016 Feb 1;11(2):e0148129.
doi: 10.1371/journal.pone.0148129. eCollection 2016. Erratum in: PLoS One.
2016;11(3):e0151452. PubMed PMID: 26829109; PubMed Central PMCID: PMC4734667.