WT161
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526418

CAS#: 1206731-57-8

Description: WT161 is a novel potent, selective, and bioavailable HDAC6 inhibitor.

Chemical Structure

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WT161
CAS# 1206731-57-8
Instruction

Theoretical Analysis

MedKoo Cat#: 526418
Name: WT161
CAS#: 1206731-57-8
Chemical Formula: C27H30N4O3
Exact Mass: 458.23
Molecular Weight: 458.562
Elemental Analysis: C, 70.72; H, 6.59; N, 12.22; O, 10.47

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 weeks
50mg USD 450 2 weeks
100mg USD 650 2 weeks
200mg USD 1050 2 weeks
500mg USD 1950 2 weeks
1g USD 2950 2 weeks
2g USD 5450 2 weeks
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Synonym: WT161; WT 161; WT-161

IUPAC/Chemical Name: (E)-8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

InChi Key: KXWWYFKVBFUVIZ-SGWCAAJKSA-N

InChi Code: InChI=1S/C27H30N4O3/c32-26(15-9-1-2-10-16-27(33)30-34)29-28-21-22-17-19-25(20-18-22)31(23-11-5-3-6-12-23)24-13-7-4-8-14-24/h3-8,11-14,17-21,34H,1-2,9-10,15-16H2,(H,29,32)(H,30,33)/b28-21+

SMILES Code: O=C(NO)CCCCCCC(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167. Epub 2016 Oct 31. PubMed PMID: 27799547; PubMed Central PMCID: PMC5135369.