WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329671

CAS#: 58186-27-9

Description: Idebenone, also known as CV 2619, ss a drug that was initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects. As of December 2013 the drug is not approved for these indications in North America or Europe, but it is approved for the treatment of Leber's hereditary optic neuropathy (LHON) in Europe.

Chemical Structure

CAS# 58186-27-9

Theoretical Analysis

MedKoo Cat#: 329671
Name: Idebenone
CAS#: 58186-27-9
Chemical Formula: C19H30O5
Exact Mass: 338.2093
Molecular Weight: 338.444
Elemental Analysis: C, 67.43; H, 8.94; O, 23.64

Price and Availability

Size Price Availability Quantity
1.0g USD 190.0 Same day
2.0g USD 350.0 Same day
5.0g USD 650.0 2 weeks
25.0g USD 1450.0 2 weeks
100.0g USD 2850.0 2 weeks
1.0kg USD 7950.0 2 weeks
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Synonym: Idebenone; CV 2619; CV-2619; CV2619; Catena, Raxone, Sovrima

IUPAC/Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone


InChi Code: InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3


Appearance: Orange Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 338.444 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Montenegro L, Modica MN, Salerno L, Panico AM, Crascì L, Puglisi G, Romeo G. In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles. Molecules. 2017 May 27;22(6). pii: E887. doi: 10.3390/molecules22060887. PubMed PMID: 28555014.

2: Yu-Wai-Man P, Soiferman D, Moore DG, Burté F, Saada A. Evaluating the therapeutic potential of idebenone and related quinone analogues in Leber hereditary optic neuropathy. Mitochondrion. 2017 Jan 16. pii: S1567-7249(17)30012-0. doi: 10.1016/j.mito.2017.01.004. [Epub ahead of print] PubMed PMID: 28093355.

3: Contin M, Buontempo F, García Becerra C, Dobrecky C, Lucangioli S, Tripodi V. New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations. J Chromatogr Sci. 2017 Mar 1;55(3):351-357. doi: 10.1093/chromsci/bmw172. PubMed PMID: 27881490.

4: Schlatter J, Bourguignon E, Majoul E, Kabiche S, Balde IB, Cisternino S, Fontan JE. Stability study of oral pediatric idebenone suspensions. Pharm Dev Technol. 2017 Mar;22(2):296-299. doi: 10.1080/10837450.2016.1231811. Epub 2016 Sep 21. PubMed PMID: 27583702.

5: Buyse GM, Voit T, Schara U, Straathof CS, D'Angelo MG, Bernert G, Cuisset JM, Finkel RS, Goemans N, Rummey C, Leinonen M, Mayer OH, Spagnolo P, Meier T, McDonald CM; DELOS Study Group. Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy. Pediatr Pulmonol. 2017 Apr;52(4):508-515. doi: 10.1002/ppul.23547. Epub 2016 Aug 29. PubMed PMID: 27571420; PubMed Central PMCID: PMC5396356.

6: Guan Y, Li J, Zhan T, Wang JW, Yu JB, Yang L. Idebenone Maintains Survival of Mutant Myocilin Cells by Inhibiting Apoptosis. Chin Med J (Engl). 2016 Aug 20;129(16):2001-4. doi: 10.4103/0366-6999.187856. PubMed PMID: 27503028; PubMed Central PMCID: PMC4989434.

7: Lauro F, Ilari S, Giancotti LA, Ventura CA, Morabito C, Gliozzi M, Malafoglia V, Palma E, Paolino D, Mollace V, Muscoli C. Pharmacological effect of a new idebenone formulation in a model of carrageenan-induced inflammatory pain. Pharmacol Res. 2016 Sep;111:767-73. doi: 10.1016/j.phrs.2016.07.043. Epub 2016 Jul 29. PubMed PMID: 27480201.

8: Gómez-Murcia V, Torrecillas A, deGodos AM, Corbalán-García S, Gómez-Fernández JC. X-ray diffraction and NMR data for the study of the location of idebenone and idebenol in model membranes. Data Brief. 2016 Mar 24;7:981-9. doi: 10.1016/j.dib.2016.03.064. eCollection 2016 Jun. PubMed PMID: 27408910; PubMed Central PMCID: PMC4927974.

9: McDonald CM, Meier T, Voit T, Schara U, Straathof CS, D'Angelo MG, Bernert G, Cuisset JM, Finkel RS, Goemans N, Rummey C, Leinonen M, Spagnolo P, Buyse GM; DELOS Study Group. Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy. Neuromuscul Disord. 2016 Aug;26(8):473-80. doi: 10.1016/j.nmd.2016.05.008. Epub 2016 May 12. PubMed PMID: 27238057.

10: Gueven N. Idebenone for Leber's hereditary optic neuropathy. Drugs Today (Barc). 2016 Mar;52(3):173-81. doi: 10.1358/dot.2016.52.3.2463564. Review. PubMed PMID: 27186591.

11: Schiff M, Rustin P. Idebenone in Friedreich ataxia and Leber's hereditary optic neuropathy: close mechanisms, similar therapy? Brain. 2016 Jul;139(Pt 7):e39. doi: 10.1093/brain/aww085. Epub 2016 Apr 19. PubMed PMID: 27095078.

12: Lyseng-Williamson KA. Idebenone: A Review in Leber's Hereditary Optic Neuropathy. Drugs. 2016 May;76(7):805-13. doi: 10.1007/s40265-016-0574-3. PubMed PMID: 27071925.

13: Gómez-Murcia V, Torrecillas A, de Godos AM, Corbalán-García S, Gómez-Fernández JC. Both idebenone and idebenol are localized near the lipid-water interface of the membrane and increase its fluidity. Biochim Biophys Acta. 2016 Jun;1858(6):1071-81. doi: 10.1016/j.bbamem.2016.02.034. Epub 2016 Feb 27. PubMed PMID: 26926421.

14: Smith TG, Seto S, Ganne P, Votruba M. A randomized, placebo-controlled trial of the benzoquinone idebenone in a mouse model of OPA1-related dominant optic atrophy reveals a limited therapeutic effect on retinal ganglion cell dendropathy and visual function. Neuroscience. 2016 Apr 5;319:92-106. doi: 10.1016/j.neuroscience.2016.01.042. Epub 2016 Jan 25. PubMed PMID: 26820596.

15: Kombath S, Balde IB, Carret S, Kabiche S, Cisternino S, Fontan JE, Schlatter J. Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms. J Anal Methods Chem. 2015;2015:835986. doi: 10.1155/2015/835986. Epub 2015 Oct 29. PubMed PMID: 26605105; PubMed Central PMCID: PMC4641926.

16: Lauro MR, Carbone C, Sansone F, Ruozi B, Chillemi R, Sciuto S, Aquino RP, Puglisi G. Innovative oral spray-dried Idebenone systems to improve patient compliance. Drug Dev Ind Pharm. 2016;42(7):1127-36. doi: 10.3109/03639045.2015.1115870. Epub 2015 Dec 1. PubMed PMID: 26556126.

17: Lin P, Liu J, Ren M, Ji K, Li L, Zhang B, Gong Y, Yan C. Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways. Biochem Biophys Res Commun. 2015 Sep 25;465(3):548-55. doi: 10.1016/j.bbrc.2015.08.058. Epub 2015 Aug 15. PubMed PMID: 26284974.

18: Seo Y, Park J, Kim M, Lee HK, Kim JH, Jeong JH, Namkung W. Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. PLoS One. 2015 Jul 21;10(7):e0133656. doi: 10.1371/journal.pone.0133656. eCollection 2015. PubMed PMID: 26196390; PubMed Central PMCID: PMC4511415.

19: Arend N, Wertheimer C, Laubichler P, Wolf A, Kampik A, Kernt M. Idebenone Prevents Oxidative Stress, Cell Death and Senescence of Retinal Pigment Epithelium Cells by Stabilizing BAX/Bcl-2 Ratio. Ophthalmologica. 2015;234(2):73-82. doi: 10.1159/000381726. Epub 2015 Jun 4. PubMed PMID: 26044821.

20: Mercuri E, Muntoni F. Efficacy of idebenone in Duchenne muscular dystrophy. Lancet. 2015 May 2;385(9979):1704-6. doi: 10.1016/S0140-6736(15)60758-9. Epub 2015 Apr 20. PubMed PMID: 25907159.