WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526339

CAS#: 91742-10-8

Description: HA-1004 is an inhibitor of PKA, cGKI, PKC, MYLK, and calcium channel protein.

Price and Availability


USD 190

USD 350

USD 650

HA-1004, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 526339
Name: HA-1004
CAS#: 91742-10-8
Chemical Formula: C12H17Cl2N5O2S
Exact Mass: 365.048
Molecular Weight: 366.261
Elemental Analysis: C, 39.35; H, 4.68; Cl, 19.36; N, 19.12; O, 8.74; S, 8.75

Synonym: HA-1004

IUPAC/Chemical Name: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide Dihydrochloride


InChi Code: InChI=1S/C12H15N5O2S.2ClH/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11;;/h1-5,8,17H,6-7H2,(H4,13,14,16);2*1H

SMILES Code: O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC(N)=N)=O.[H]Cl.[H]Cl

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Almela P, García-Carmona JA, Martínez-Laorden E, Milanés MV, Laorden ML. Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal. Front Pharmacol. 2013 Dec 27;4:164. doi: 10.3389/fphar.2013.00164. eCollection 2013. PubMed PMID: 24409147; PubMed Central PMCID: PMC3873507.

2: Villarruel EQ, Borda E, Sterin-Borda L, Orman B. Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity. Cell Biol Int. 2011 Aug;35(8):783-8. doi: 10.1042/CBI20100200. PubMed PMID: 21047305.

3: Almela P, Atucha NM, Milanés MV, Laorden ML. Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. J Pharmacol Exp Ther. 2009 Sep;330(3):771-82. doi: 10.1124/jpet.109.154583. Epub 2009 Jun 30. PubMed PMID: 19567779.

4: Varga F, Rumpler M, Spitzer S, Karlic H, Klaushofer K. Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts. Endocr J. 2009;56(3):441-50. Epub 2009 Feb 18. PubMed PMID: 19225217.

5: Almela P, Victoria Milanés M, Luisa Laorden M. Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle. Basic Res Cardiol. 2009 Jul;104(4):366-76. doi: 10.1007/s00395-008-0768-2. Epub 2008 Dec 22. PubMed PMID: 19104749.

6: Almela P, Milanés M, Laorden M. The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. Br J Pharmacol. 2008 Sep;155(1):73-83. doi: 10.1038/bjp.2008.224. Epub 2008 Jun 9. PubMed PMID: 18536752; PubMed Central PMCID: PMC2527841.

7: Almela P, Cerezo M, González-Cuello A, Milanés MV, Laorden ML. Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):293-303. Epub 2006 Nov 25. PubMed PMID: 17216288.

8: Schach C, Xu M, Platoshyn O, Keller SH, Yuan JX. Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels. Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L685-98. Epub 2006 Nov 10. PubMed PMID: 17098807.

9: Ghosh M, Gharami K, Paul S, Das S. Thyroid hormone-induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signalling pathway. Eur J Neurosci. 2005 Oct;22(7):1609-17. PubMed PMID: 16197501.

10: Broccardo CJ, Billings RE, Andersen ME, Hanneman WH. Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells. Toxicol Sci. 2005 Nov;88(1):82-94. Epub 2005 Aug 4. PubMed PMID: 16081525.

11: Kochel I, Rapak A, Ziolo E, Strzadala L. Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1102-6. PubMed PMID: 16051191.

12: Kubo T, Hagiwara Y. Protein kinase C activation-induced increases of neural activity are enhanced in the hypothalamus of spontaneously hypertensive rats. Brain Res. 2005 Feb 8;1033(2):157-63. PubMed PMID: 15694920.

13: Benavides M, Laorden ML, Milanés MV. Involvement of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups. J Neurochem. 2005 Jan;92(2):246-54. PubMed PMID: 15663473.

14: Shen KZ, Johnson SW. Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus. J Physiol. 2003 Dec 1;553(Pt 2):489-96. Epub 2003 Sep 18. PubMed PMID: 14500768; PubMed Central PMCID: PMC2343573.

15: Wainszelbaum MJ, Belaunzarán ML, Lammel EM, Florin-Christensen M, Florin-Christensen J, Isola EL. Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi. Biochem J. 2003 Nov 1;375(Pt 3):705-12. PubMed PMID: 12887332; PubMed Central PMCID: PMC1223715.

16: Miyoshi K, Kawakami N, Horio S, Fukui H. Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):343-7. PubMed PMID: 12851655.

17: Kalas W, Matuszyk J, Ziolo E, Strzadala L. FK506 restores sensitivity of thymic lymphomas to calcium-mediated apoptosis and the inducible expression of Fas ligand. Anticancer Res. 2003 Mar-Apr;23(2B):1613-7. PubMed PMID: 12820430.

18: Martínez MD, Milanés MV, Laorden ML. Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart. Eur J Pharmacol. 2003 Jun 20;471(2):113-9. PubMed PMID: 12818698.

19: Cerezo M, Laorden ML, Milanés MV. Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis. Eur J Pharmacol. 2002 Sep 27;452(1):57-66. PubMed PMID: 12323385.

20: Matuszyk J, Cebrat M, Kalas W, Strzadala L. HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism. Int Immunopharmacol. 2002 Mar;2(4):435-42. PubMed PMID: 11962723.