WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526338

CAS#: 6559-91-7

Description: 4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.

Price and Availability


USD 190
USD 1050

USD 350
USD 1650

USD 650

4'-Demethylepipodophyllotoxin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 526338
Name: 4'-Demethylepipodophyllotoxin
CAS#: 6559-91-7
Chemical Formula: C21H20O8
Exact Mass: 400.1158
Molecular Weight: 400.383
Elemental Analysis: C, 63.00; H, 5.04; O, 31.97

Synonym: 4'-Demethylepipodophyllotoxin

IUPAC/Chemical Name: (5R-(5alpha,5abeta,8aalpha,9beta))-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one


InChi Code: InChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1

SMILES Code: O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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20: Yang TM, Guo SF, Chen CR, Zhang XY, Li WG. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. doi: 10.1211/jpp.60.2.0006. PubMed PMID: 18237465.