WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558264

CAS#: 41501-64-8

Description: MAC173979 is a novel inhibitor of E. coli de novo PABA biosynthesis and growth.

Chemical Structure

CAS# 41501-64-8

Theoretical Analysis

MedKoo Cat#: 558264
Name: MAC173979
CAS#: 41501-64-8
Chemical Formula: C9H5Cl2NO3
Exact Mass: 244.9646
Molecular Weight: 246.043
Elemental Analysis: C, 43.94; H, 2.05; Cl, 28.82; N, 5.69; O, 19.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MAC173979; MAC-173979; MAC 173979.

IUPAC/Chemical Name: 3,3-Dichloro-1-(3-nitrophenyl)prop-2-en-1-one


InChi Code: InChI=1S/C9H5Cl2NO3/c10-9(11)5-8(13)6-2-1-3-7(4-6)12(14)15/h1-5H

SMILES Code: O=C(C1=CC=CC([N+]([O-])=O)=C1)/C=C(Cl)\Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 246.043 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083. PubMed PMID: 27905500; PubMed Central PMCID: PMC5131483.

2: Zlitni S, Ferruccio LF, Brown ED. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol. 2013 Dec;9(12):796-804. doi: 10.1038/nchembio.1361. Epub 2013 Oct 13. PubMed PMID: 24121552; PubMed Central PMCID: PMC3970981.