MAC173979

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526280

CAS#: 41501-64-8

Description: MAC173979 is a novel inhibitor of E. coli de novo PABA biosynthesis and growth.


Price and Availability

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Price

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MAC173979 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526280
Name: MAC173979
CAS#: 41501-64-8
Chemical Formula: C9H5Cl2NO3
Exact Mass: 244.9646
Molecular Weight: 246.043
Elemental Analysis: C, 43.94; H, 2.05; Cl, 28.82; N, 5.69; O, 19.51


Synonym: MAC173979; MAC-173979; MAC 173979.

IUPAC/Chemical Name: 3,3-Dichloro-1-(3-nitrophenyl)prop-2-en-1-one

InChi Key: OGORZYUCNNDKIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H5Cl2NO3/c10-9(11)5-8(13)6-2-1-3-7(4-6)12(14)15/h1-5H

SMILES Code: O=C(C1=CC=CC([N+]([O-])=O)=C1)/C=C(Cl)\Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083. PubMed PMID: 27905500; PubMed Central PMCID: PMC5131483.

2: Zlitni S, Ferruccio LF, Brown ED. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol. 2013 Dec;9(12):796-804. doi: 10.1038/nchembio.1361. Epub 2013 Oct 13. PubMed PMID: 24121552; PubMed Central PMCID: PMC3970981.