ELN484228
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526250

CAS#: 312-63-0

Description: ELN484228 is a cell-permeable alpha-Synuclein Blocker.

Chemical Structure

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ELN484228
CAS# 312-63-0
Instruction

Theoretical Analysis

MedKoo Cat#: 526250
Name: ELN484228
CAS#: 312-63-0
Chemical Formula: C12H10FNO2S
Exact Mass: 251.04
Molecular Weight: 251.275
Elemental Analysis: C, 57.36; H, 4.01; F, 7.56; N, 5.57; O, 12.73; S, 12.76

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 weeks
200mg USD 650 2 weeks
500mg USD 1450 2 weeks
1g USD 2450 2 weeks
2g USD 3950 2 weeks
5g USD 5950 2 weeks
Bulk inquiry

Synonym: ELN484228; ELN-484228; ELN 484228.

IUPAC/Chemical Name: N-(4-Fluorophenyl)benzenesulfonamide

InChi Key: AZORQGXJAXEIGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H

SMILES Code: O=S(C1=CC=CC=C1)(NC2=CC=C(F)C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 251.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014 Feb 14;9(2):e87133. doi: 10.1371/journal.pone.0087133. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99274. PubMed PMID: 24551051; PubMed Central PMCID: PMC3925190.