OB-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526107

CAS#: 300803-69-4

Description: OB-1 is a novel inhibitor of stomatin-like protein-3 (STOML3) oligomerization that reversibly reduce the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.


Chemical Structure

img
OB-1
CAS# 300803-69-4

Theoretical Analysis

MedKoo Cat#: 526107
Name: OB-1
CAS#: 300803-69-4
Chemical Formula: C21H17N3O6
Exact Mass: 407.11
Molecular Weight: 407.382
Elemental Analysis: C, 61.92; H, 4.21; N, 10.31; O, 23.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: OB-1

IUPAC/Chemical Name: 5-(3-Methyl-5-nitro-3H-imidazol-4-yloxy)-2-phenyl-benzofuran-3-carboxylic acid ethyl ester

InChi Key: UJHGRDVYTTVJFD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17N3O6/c1-3-28-21(25)17-15-11-14(29-20-19(24(26)27)22-12-23(20)2)9-10-16(15)30-18(17)13-7-5-4-6-8-13/h4-12H,3H2,1-2H3

SMILES Code: O=C(C1=C(C2=CC=CC=C2)OC3=CC=C(OC4=C([N+]([O-])=O)N=CN4C)C=C13)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Vileigas DF, de Deus AF, da Silva DC, de Tomasi LC, de Campos DH, Adorni CS, de Oliveira SM, Sant'Ana PG, Okoshi K, Padovani CR, Cicogna AC. Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β-adrenergic system and does not compromise cardiac function. Physiol Rep. 2016 Sep;4(17). pii: e12914. doi: 10.14814/phy2.12914. PubMed PMID: 27582064; PubMed Central PMCID: PMC5027348.

2: Raju J, Roberts J, Chen Q, Aziz SA, Caldwell D, Bird RP, Scoggan KA, Brooks SP. Fermentable Carbohydrates Differentially Affect Colon Tumor Formation in Azoxymethane-Induced Male Fischer 344 Rats. J Nutr. 2016 Mar 9. pii: jn214833. [Epub ahead of print] PubMed PMID: 26962187.

3: Martins BC, Plummer CE, Gelatt KN, Brooks DE, Czerwinski SE, Monk C, Greenberg SM, Mangan BG, Londoño L, Bolfer L, Bandt C, Schaer M. Ophthalmic abnormalities secondary to periocular or ocular snakebite (pit vipers) in dogs--11 cases (2012-2014). Vet Ophthalmol. 2016 Mar;19(2):149-60. doi: 10.1111/vop.12276. Epub 2015 Apr 24. PubMed PMID: 25912317.

4: Liechty JM, Lee MJ. Body size estimation and other psychosocial risk factors for obesity onset among US adolescents: findings from a longitudinal population level study. Int J Obes (Lond). 2015 Apr;39(4):601-7. doi: 10.1038/ijo.2014.191. Epub 2014 Nov 5. PubMed PMID: 25370575.

5: Gao S, Calcagni M, Welti M, Hemmi S, Hild N, Stark WJ, Bürgisser GM, Wanner GA, Cinelli P, Buschmann J. Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts. Injury. 2014 Jun;45(6):974-80. doi: 10.1016/j.injury.2014.02.035. Epub 2014 Mar 12. PubMed PMID: 24650943.

6: Malatesta D, Vismara L, Menegoni F, Grugni G, Capodaglio P. Effect of obesity onset on pendular energy transduction at spontaneous walking speed: Prader-Willi versus nonsyndromal obese individuals. Obesity (Silver Spring). 2013 Dec;21(12):E586-91. doi: 10.1002/oby.20455. Epub 2013 Jun 13. PubMed PMID: 23554340.

7: Shin HY, Chung S, Kim SR, Lee JH, Seo HS, Shin YC, Ko SG. The Extract of Herbal Medicines Activates AMP-Activated Protein Kinase in Diet-Induced Obese Rats. Evid Based Complement Alternat Med. 2013;2013:756025. doi: 10.1155/2013/756025. Epub 2013 Mar 7. PubMed PMID: 23533517; PubMed Central PMCID: PMC3606713.

8: Bradshaw PT, Monda KL, Stevens J. Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the Atherosclerosis Risk in Communities Study. Obesity (Silver Spring). 2013 Jan;21(1):203-9. doi: 10.1002/oby.20248. PubMed PMID: 23505187; PubMed Central PMCID: PMC4170589.

9: Nikitin AP, Stocks NG, Bulsara AR. Enhancing the resolution of a sensor via negative correlation: a biologically inspired approach. Phys Rev Lett. 2012 Dec 7;109(23):238103. Epub 2012 Dec 5. PubMed PMID: 23368270.

10: Reichl FX, Löhle J, Seiss M, Furche S, Shehata MM, Hickel R, Müller M, Dränert M, Durner J. Elution of TEGDMA and HEMA from polymerized resin-based bonding systems. Dent Mater. 2012 Nov;28(11):1120-5. doi: 10.1016/j.dental.2012.06.010. Epub 2012 Sep 18. PubMed PMID: 22995638.

11: Vincenti GM, Ambrosio G, Hyacinthe JN, Quercioli A, Seimbille Y, Mach F, Ratib O, Vallée JP, Schindler TH. Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight. J Nucl Cardiol. 2012 Aug;19(4):693-703. doi: 10.1007/s12350-012-9570-5. Epub 2012 Apr 28. PubMed PMID: 22544436.

12: Norris AL, Steinberger J, Steffen LM, Metzig AM, Schwarzenberg SJ, Kelly AS. Circulating oxidized LDL and inflammation in extreme pediatric obesity. Obesity (Silver Spring). 2011 Jul;19(7):1415-9. doi: 10.1038/oby.2011.21. Epub 2011 Feb 17. PubMed PMID: 21331062; PubMed Central PMCID: PMC3684410.

13: Wang FS, Chen H, Wu ZY, Lin JH. KISS1 expression in osteosarcoma: high in chinese clinical cases, but lower in cell lines. Asian Pac J Cancer Prev. 2011;12(12):3229-34. PubMed PMID: 22471458.

14: Agnew A, Calderwood D, Chevallier OP, Greer B, Grieve DJ, Green BD. Chronic treatment with a stable obestatin analog significantly alters plasma triglyceride levels but fails to influence food intake; fluid intake; body weight; or body composition in rats. Peptides. 2011 Apr;32(4):755-62. doi: 10.1016/j.peptides.2010.12.005. Epub 2010 Dec 16. PubMed PMID: 21167891.

15: Maté D, García-Burgos C, García-Ruiz E, Ballesteros AO, Camarero S, Alcalde M. Laboratory evolution of high-redox potential laccases. Chem Biol. 2010 Sep 24;17(9):1030-41. doi: 10.1016/j.chembiol.2010.07.010. PubMed PMID: 20851352.

16: Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Gómez-Ambrosi J, Frühbeck G. Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice. Mediators Inflamm. 2010;2010:784343. doi: 10.1155/2010/784343. Epub 2010 Jun 30. PubMed PMID: 20671928; PubMed Central PMCID: PMC2910527.

17: Ciarapica D, Mauro B, Zaccaria M, Cannella C, Polito A. Validity of self-reported body weight and height among women including patients with eating disorders. Eat Weight Disord. 2010 Mar-Jun;15(1-2):e74-80. PubMed PMID: 20571324.

18: Owens LA, O'Sullivan EP, Kirwan B, Avalos G, Gaffney G, Dunne F; ATLANTIC DIP Collaborators. ATLANTIC DIP: the impact of obesity on pregnancy outcome in glucose-tolerant women. Diabetes Care. 2010 Mar;33(3):577-9. doi: 10.2337/dc09-0911. Epub 2010 Jan 12. PubMed PMID: 20067952; PubMed Central PMCID: PMC2827510.

19: Gaintantzopoulou M, Kakaboura A, Loukidis M, Vougiouklakis G. A study on colour stability of self-etching and etch-and-rinse adhesives. J Dent. 2009 May;37(5):390-6. doi: 10.1016/j.jdent.2009.01.010. Epub 2009 Feb 23. PubMed PMID: 19237236.

20: Fernandez-Obregon AC. Clinical management with efalizumab of a patient with psoriasis and comorbid vitiligo. J Drugs Dermatol. 2008 Jul;7(7):679-81. PubMed PMID: 18664161.