WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533009
CAS#: 1420290-99-8
Description: HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC).
MedKoo Cat#: 533009
Name: HJC0152
CAS#: 1420290-99-8
Chemical Formula: C15H14Cl3N3O4
Exact Mass:
Molecular Weight: 406.64
Elemental Analysis: C, 44.31; H, 3.47; Cl, 26.15; N, 10.33; O, 15.74
Synonym: HJC0152; HJC 0152; HJC-0152.
IUPAC/Chemical Name: 2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride
InChi Key: XRZHLOYBZOONSZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H13Cl2N3O4.ClH/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17;/h1-4,7-8H,5-6,18H2,(H,19,21);1H
SMILES Code: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl
1: Wang Y, Wang S, Wu Y, Ren Y, Li Z, Yao X, Zhang C, Ye N, Jing C, Dong J, Zhang K, Sun S, Zhao M, Guo W, Qu X, Qiao Y, Chen H, Kong L, Jin R, Wang X, Zhang L, Zhou J, Shen Q, Zhou X. Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152. Mol Cancer Ther. 2017 Apr;16(4):578-590. doi: 10.1158/1535-7163.MCT-16-0606. Epub 2017 Jan 30. PubMed PMID: 28138036; PubMed Central PMCID: PMC5380531.