NSC16168

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MedKoo CAT#: 526047

CAS#: 6837-93-0

Description: NSC16168 is a specific inhibitor of ERCC1-XPF with no effect on both HhaI and XPG.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC16168 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526047
Name: NSC16168
CAS#: 6837-93-0
Chemical Formula: C17H15NO9S3
Exact Mass: 472.9909
Molecular Weight: 473.485
Elemental Analysis: C, 43.12; H, 3.19; N, 2.96; O, 30.41; S, 20.31


Synonym: NSC16168

IUPAC/Chemical Name: 4-Amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid

InChi Key: ZIQWUYNDHGXLIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15NO9S3/c1-10-2-4-12(5-3-10)30(25,26)27-16-9-14(29(22,23)24)7-11-6-13(28(19,20)21)8-15(18)17(11)16/h2-9H,18H2,1H3,(H,19,20,21)(H,22,23,24)

SMILES Code: O=S(C1=CC(N)=C2C(OS(=O)(C3=CC=C(C)C=C3)=O)=CC(S(=O)(O)=O)=CC2=C1)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Arora S, Heyza J, Zhang H, Kalman-Maltese V, Tillison K, Floyd AM, Chalfin EM, Bepler G, Patrick SM. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117. doi: 10.18632/oncotarget.12072. PubMed PMID: 27650543; PubMed Central PMCID: PMC5342726.