WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532984
Description: YM 218 is a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist.
MedKoo Cat#: 532984
Name: YM 218
Chemical Formula: C35H38F2N4O4
Exact Mass: 616.2861
Molecular Weight: 616.71
Elemental Analysis: C, 68.17; H, 6.21; F, 6.16; N, 9.08; O, 10.38
This product is not in stock, which may be available by custom synthesis.
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Synonym: YM 218; YM-218; YM218.
IUPAC/Chemical Name: N-[4-[(5Z)-4,4-difluoro-5-[2-oxo-2-(4-piperidin-1-ylpiperidin-1-yl)ethylidene]2,3-dihydro-1-benzazepine-1-carbonyl]phenyl]-2-methylfuran-3-carboxamide
InChi Key: VDUUABBYYOPFAW-WMMMYUQOSA-N
InChi Code: InChI=1S/C35H38F2N4O4/c1-24-28(15-22-45-24)33(43)38-26-11-9-25(10-12-26)34(44)41-21-16-35(36,37)30(29-7-3-4-8-31(29)41)23-32(42)40-19-13-27(14-20-40)39-17-5-2-6-18-39/h3-4,7-12,15,22-23,27H,2,5-6,13-14,16-21H2,1H3,(H,38,43)/b30-23-
SMILES Code: O=C(C1=C(C)OC=C1)NC2=CC=C(C(N3CCC(F)(F)/C(C4=CC=CC=C43)=C\C(N5CCC(N6CCCCC6)CC5)=O)=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 616.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Tahara A, Tsukada J, Tomura Y, Suzuki T, Yatsu T, Shibasaki M. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Vascul Pharmacol. 2007 Jun;46(6):463-9. Epub 2007 Mar 1. PubMed PMID: 17395547.