WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532981
CAS#: 1640226-17-0 (HCl)
Description: YIL781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). YIL781 displays no significant affinity for the motilin receptor (Ki = 6 μM). It bBlocks the effects of ghrelin on insulin secretion both in vivo and in vitro.
MedKoo Cat#: 532981
Name: YIL781 HCl
CAS#: 1640226-17-0 (HCl)
Chemical Formula: C24H29ClFN3O2
Exact Mass: 409.2166
Molecular Weight: 445.9634
Elemental Analysis: C, 64.64; H, 6.55; Cl, 7.95; F, 4.26; N, 9.42; O, 7.18
Related CAS #: 875258-85-8 (free base) 1640226-17-0 (HCl)
Synonym: YIL781; YIL 781; YIL-781; YIL781 HCl; YIL781 hydrochloride
IUPAC/Chemical Name: 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]quinazolin-4-one hydrochloride
InChi Key: QQGRMONBDBMLSP-FERBBOLQSA-N
InChi Code: InChI=1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
SMILES Code: O=C1N(C[C@@H]2CN(C(C)C)CCC2)C(C)=NC3=C1C=C(OC4=CC=C(F)C=C4)C=C3.[H]Cl
Appearance: White to light yellow solid powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 445.9634 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development? Endocrinology 150 2526. PMID: 19372201.
2. Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175. PMID: 17656463.