XCT790
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MedKoo CAT#: 532977

CAS#: 725247-18-7

Description: XCT790 is a selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). XCT790 displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. It interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling.

Chemical Structure

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XCT790
CAS# 725247-18-7
Instruction

Theoretical Analysis

MedKoo Cat#: 532977
Name: XCT790
CAS#: 725247-18-7
Chemical Formula: C23H13F9N4O3S
Exact Mass: 596.06
Molecular Weight: 596.430
Elemental Analysis: C, 46.32; H, 2.20; F, 28.67; N, 9.39; O, 8.05; S, 5.38

Price and Availability

Size Price Availability Quantity
5mg USD 190
10mg USD 350
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Synonym: XCT790; XCT 790; XCT-790.

IUPAC/Chemical Name: (E)-3-[4-[[2, 4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5- (trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide

InChi Key: HQFNFOOGGLSBBT-AWNIVKPZSA-N

InChi Code: InChI=1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+

SMILES Code: O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)C(OC)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 596.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lu YH, Li QY, Chen L, Shi XJ. [XCT790 inhibits rat vascular smooth muscle cells proliferation through down-regulating the expression of estrogen-related receptor alpha]. Yao Xue Xue Bao. 2014 Feb;49(2):190-7. Chinese. PubMed PMID: 24761608.

2: Lanvin O, Bianco S, Kersual N, Chalbos D, Vanacker JM. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790. J Biol Chem. 2007 Sep 28;282(39):28328-34. Epub 2007 Jul 12. PubMed PMID: 17631492.