WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532976
CAS#: 196928-50-4
Description: XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.
MedKoo Cat#: 532976
Name: XAP044
CAS#: 196928-50-4
Chemical Formula: C15H9IO4
Exact Mass: 379.9546
Molecular Weight: 380.14
Elemental Analysis: C, 47.39; H, 2.39; I, 33.38; O, 16.83
Synonym: XAP044; XAP 044; XAP-044
IUPAC/Chemical Name: 7-hydroxy-3-(4-iodophenoxy)chromen-4-one
InChi Key: XXZKJJYWINSUMJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
SMILES Code: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
Appearance: White to beige solid powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 380.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089.
