XAP044
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532976

CAS#: 196928-50-4

Description: XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.


Price and Availability

Size
Price

5mg
USD 190
Size
Price

10mg
USD 350
Size
Price

XAP044, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532976
Name: XAP044
CAS#: 196928-50-4
Chemical Formula: C15H9IO4
Exact Mass: 379.9546
Molecular Weight: 380.14
Elemental Analysis: C, 47.39; H, 2.39; I, 33.38; O, 16.83


Synonym: XAP044; XAP 044; XAP-044

IUPAC/Chemical Name: 7-hydroxy-3-(4-iodophenoxy)chromen-4-one

InChi Key: XXZKJJYWINSUMJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H

SMILES Code: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3


Technical Data

Appearance:
White to beige solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089.