XAP044
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532976

CAS#: 196928-50-4

Description: XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.


Chemical Structure

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XAP044
CAS# 196928-50-4

Theoretical Analysis

MedKoo Cat#: 532976
Name: XAP044
CAS#: 196928-50-4
Chemical Formula: C15H9IO4
Exact Mass: 379.95
Molecular Weight: 380.140
Elemental Analysis: C, 47.39; H, 2.39; I, 33.38; O, 16.83

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
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Synonym: XAP044; XAP 044; XAP-044

IUPAC/Chemical Name: 7-hydroxy-3-(4-iodophenoxy)chromen-4-one

InChi Key: XXZKJJYWINSUMJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H

SMILES Code: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3

Appearance: White to beige solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 380.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089.