DBPR211
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MedKoo CAT#: 525943

CAS#: 1429239-98-4

Description: DBPR211, also known as CB1-IN-1, is a novel potent CB1 receptor agonist. DBPR211 possesses an extremely low brain to plasma ratio. It significantly improves insulin resistance in diabetic models, and induces weight loss and decreases hepatic steatosis as well as insulin resistance in obese model. This drug candidate is well protected by various global patent applications. IBPR/NHRI will seek for industrial partner to further develop DBPR211, and clinical trials will be conducted after technical transfer in the near future.


Chemical Structure

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DBPR211
CAS# 1429239-98-4

Theoretical Analysis

MedKoo Cat#: 525943
Name: DBPR211
CAS#: 1429239-98-4
Chemical Formula: C33H31Cl2F3N6O3S2
Exact Mass: 750.12
Molecular Weight: 751.665
Elemental Analysis: C, 52.73; H, 4.16; Cl, 9.43; F, 7.58; N, 11.18; O, 6.39; S, 8.53

Price and Availability

Size Price Availability Quantity
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 750 Ready to ship
200mg USD 1250 Ready to ship
500mg USD 2650 Ready to ship
1g USD 3850 Ready to ship
2g USD 6450 2 Weeks
Bulk inquiry

Synonym: DBPR211; DBPR 211; DBPR-211; CB1-IN-1; CB1-IN 1; CB1-IN1;

IUPAC/Chemical Name: 1-(2,4-Dichloro-phenyl)-4-[(pyrrolidine-1-sulfonylamino)-methyl]-5-[5-(4-trifluoromethyl-phenylethynyl)-thiophen-2-yl]-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

InChi Key: KAIYFJUWIBTYPK-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H31Cl2F3N6O3S2/c34-24-11-14-28(27(35)20-24)44-31(29-15-13-25(48-29)12-8-22-6-9-23(10-7-22)33(36,37)38)26(21-39-49(46,47)43-18-4-5-19-43)30(40-44)32(45)41-42-16-2-1-3-17-42/h6-7,9-11,13-15,20,39H,1-5,16-19,21H2,(H,41,45)

SMILES Code: O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CNS(=O)(N5CCCC5)=O)NN6CCCCC6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 751.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chang CP, Huang HL, Huang JK, Hung MS, Wu CH, Song JS, Lee CJ, Yu CS, Shia KS.
Fluorine-18 isotope labeling for positron emission tomography imaging. Direct
evidence for DBPR211 as a peripherally restricted CB1 inverse agonist. Bioorg Med
Chem. 2019 Jan 1;27(1):216-223. doi: 10.1016/j.bmc.2018.11.043. Epub 2018 Nov 29.
PubMed PMID: 30528163.