MEK Inhibitor I

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525897

CAS#: 297744-42-4

Description: MEK Inhibitor I is a selective and potent inhibitor of MEK.


Chemical Structure

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MEK Inhibitor I
CAS# 297744-42-4

Theoretical Analysis

MedKoo Cat#: 525897
Name: MEK Inhibitor I
CAS#: 297744-42-4
Chemical Formula: C21H18N4OS
Exact Mass: 374.12
Molecular Weight: 374.462
Elemental Analysis: C, 67.36; H, 4.85; N, 14.96; O, 4.27; S, 8.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MEK Inhibitor I; MEK-IN-4; NEN44424; NEN-44424; NEN 44424;

IUPAC/Chemical Name: 3-Amino-3-(2-amino-phenylsulfanyl)-2-[3-(hydroxy-pyridin-4-yl-methyl)-phenyl]-acrylonitrile

InChi Key: NHBMKTBZZSJUGA-FXBPSFAMSA-N

InChi Code: InChI=1S/C21H18N4OS/c22-13-17(21(24)27-19-7-2-1-6-18(19)23)15-4-3-5-16(12-15)20(26)14-8-10-25-11-9-14/h1-12,20,26H,23-24H2/b21-17-

SMILES Code: N#C/C(C1=CC=CC(C(O)C2=CC=NC=C2)=C1)=C(N)/SC3=CC=CC=C3N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Johnson D. Is there a role for single-agent MEK inhibition in melanoma? Clin Adv Hematol Oncol. 2016 Dec;14(12):976-978. PubMed PMID: 28212360.

2: Thomas CL, Mortimer PS, Larkin JM, Basu TN, Gore ME, Fearfield L. A mitogen-activated protein kinase kinase inhibitor induced compound skin toxicity with oedema in metastatic malignant melanoma. Clin Exp Dermatol. 2016 Apr;41(3):267-71. doi: 10.1111/ced.12722. Epub 2015 Sep 28. PubMed PMID: 26411345.

3: Crassini K, Stevenson WS, Mulligan SP, Best OG. The MEK1/2 inhibitor, MEKi-1, induces cell death in chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine. Leuk Lymphoma. 2015;56(12):3407-17. doi: 10.3109/10428194.2015.1032963. Epub 2015 Aug 26. PubMed PMID: 25804768.

4: Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 2011 Jun 3;286(22):19439-45. doi: 10.1074/jbc.M110.210294. Epub 2011 Apr 12. PubMed PMID: 21487005; PubMed Central PMCID: PMC3103323.