Autophinib
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MedKoo CAT#: 525896

CAS#: 1644443-47-9

Description: Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 190 Same Day
50mg USD 350 Same Day
100mg USD 550 Same Day
200mg USD 850 Same Day
500mg USD 1450 Same Day
1g USD 2850 Same Day
2g USD 4650 Same Day
5g USD 7950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

Autophinib, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525896
Name: Autophinib
CAS#: 1644443-47-9
Chemical Formula: C14H11ClN6O3
Exact Mass: 346.0581
Molecular Weight: 346.731
Elemental Analysis: C, 48.50; H, 3.20; Cl, 10.22; N, 24.24; O, 13.84


Synonym: Autophinib

IUPAC/Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine

InChi Key: CEUMAXLRGBKFQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)

SMILES Code: O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Waldmann H, Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Wu Y, Engel J. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 May 22. doi: 10.1002/anie.201703738. [Epub ahead of print] PubMed PMID: 28544137.