WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525896
CAS#: 1644443-47-9
Description: Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
MedKoo Cat#: 525896
Name: Autophinib
CAS#: 1644443-47-9
Chemical Formula: C14H11ClN6O3
Exact Mass: 346.0581
Molecular Weight: 346.731
Elemental Analysis: C, 48.50; H, 3.20; Cl, 10.22; N, 24.24; O, 13.84
Synonym: Autophinib
IUPAC/Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine
InChi Key: CEUMAXLRGBKFQP-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)
SMILES Code: O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]
1: Waldmann H, Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Wu Y, Engel J. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 May 22. doi: 10.1002/anie.201703738. [Epub ahead of print] PubMed PMID: 28544137.