WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532966
Description: WB 4101 hydrochloride is a α1A-adrenergic selective antagonist.
MedKoo Cat#: 532966
Name: WB 4101 hydrochloride
Chemical Formula: C19H24ClNO5
Molecular Weight: 381.85
Elemental Analysis: C, 59.76; H, 6.34; Cl, 9.28; N, 3.67; O, 20.95
Related CAS #: 2170-58-3 (HCl) 613-67-2 (free)
Synonym: WB 4101; WB-4101; WB4101; WB 4101 hydrochloride; WB 4101 HCl.
IUPAC/Chemical Name: 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride
InChi Key: KAHMEWANVDFFCQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H23NO5.ClH/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14;/h3-9,14,20H,10-13H2,1-2H3;1H
SMILES Code: COC1=C(OCCNCC2OC3=CC=CC=C3OC2)C(OC)=CC=C1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 381.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428.
2. Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321. PMID: 3010073.
3. Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326. PMID: 5791620.