WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532964

CAS#: 868359-05-1

Description: WAY-213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). WAY-213613 exhibits no activity towards ionotropic and metabotropic glutamate receptors.

Chemical Structure

CAS# 868359-05-1

Theoretical Analysis

MedKoo Cat#: 532964
Name: WAY-213613
CAS#: 868359-05-1
Chemical Formula: C16H13BrF2N2O4
Exact Mass: 414.0027
Molecular Weight: 415.19
Elemental Analysis: C, 46.29; H, 3.16; Br, 19.25; F, 9.15; N, 6.75; O, 15.41

Price and Availability

Size Price Availability Quantity
10.0mg USD 425.0 2 Weeks
50.0mg USD 1650.0 2 Weeks
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Synonym: WAY-213613; WAY 213613; WAY213613.

IUPAC/Chemical Name: (2S)-2-amino-3-{[4-(2-bromo-4,5-difluorophenoxy)phenyl]carbamoyl}propanoic acid


InChi Code: InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1

SMILES Code: O=C(O)[C@@H](N)CC(NC1=CC=C(OC2=CC(F)=C(F)C=C2Br)C=C1)=O

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 415.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P. Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells. Neuroscience. 2009 Jul 7;161(3):794-805. doi: 10.1016/j.neuroscience.2009.04.017. Epub 2009 Apr 11. PubMed PMID: 19364521.

2: Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. PubMed PMID: 16014807.