WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525871

CAS#: 484-20-8

Description: Bergapten is an anti-convulsant, showing activity against T. muris.

Price and Availability


USD 190

USD 420

Bergapten purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525871
Name: Bergapten
CAS#: 484-20-8
Chemical Formula: C12H8O4
Exact Mass: 216.0423
Molecular Weight: 216.192
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Synonym: Bergapten

IUPAC/Chemical Name: 4-Methoxyfuro[3,2-g]chromen-7-one


InChi Code: InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Zhang HL, Wu XY, Mi J, Peng YJ, Wang ZG, Liu Y, Wu XL, Gao Y. A new anti-inflammatory alkaloid from roots of Heracleum dissectum. Chem Biodivers. 2017 May 27. doi: 10.1002/cbdv.201700184. [Epub ahead of print] PubMed PMID: 28556437.

2: Zhou Y, Wang J, Yang W, Qi X, Lan L, Luo L, Yin Z. Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge. Int Immunopharmacol. 2017 May 13;48:159-168. doi: 10.1016/j.intimp.2017.04.026. [Epub ahead of print] PubMed PMID: 28511114.

3: Rajtar B, Skalicka-Woźniak K, Świątek Ł, Stec A, Boguszewska A, Polz-Dacewicz M. Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections. Food Chem Toxicol. 2017 May 6. pii: S0278-6915(17)30239-9. doi: 10.1016/j.fct.2017.05.011. [Epub ahead of print] PubMed PMID: 28487231.

4: Zheng Y, Xu X, Yuan F, Yao M, Ji S, Huang Z, Zhang F. Simultaneous Analysis of Simple Coumarins and Furocoumarines in Cigarettes by Solid-Phase Extraction with Gas Chromatography-Mass Spectrometry. J AOAC Int. 2017 Apr 20. doi: 10.5740/jaoacint.16-0192. [Epub ahead of print] PubMed PMID: 28425389.

5: Azietaku JT, Ma H, Yu XA, Li J, Oppong MB, Cao J, An M, Chang YX. A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum. J Ethnopharmacol. 2017 Apr 18;202:241-255. doi: 10.1016/j.jep.2017.03.022. Epub 2017 Mar 21. Review. PubMed PMID: 28336469.

6: Melough MM, Vance TM, Lee SG, Provatas AA, Perkins C, Qureshi A, Cho E, Chun OK. Furocoumarin Kinetics in Plasma and Urine of Healthy Adults Following Consumption of Grapefruit (Citrus paradisi Macf.) and Grapefruit Juice. J Agric Food Chem. 2017 Mar 29. doi: 10.1021/acs.jafc.7b00317. [Epub ahead of print] PubMed PMID: 28322044.

7: Wrześniok D, Beberok A, Rok J, Delijewski M, Hechmann A, Oprzondek M, Rzepka Z, Bacler-Żbikowska B, Buszman E. UVA radiation augments cytotoxic activity of psoralens in melanoma cells. Int J Radiat Biol. 2017 Mar 13:1-6. doi: 10.1080/09553002.2017.1297903. [Epub ahead of print] PubMed PMID: 28287037.

8: Teye Azietaku J, Yu XA, Li J, Hao J, Cao J, An M, Tan Z, Chang YX. Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract. Int J Anal Chem. 2016;2016:9507246. doi: 10.1155/2016/9507246. Epub 2016 Dec 26. PubMed PMID: 28115935; PubMed Central PMCID: PMC5220503.

9: Madeiro SA, Borges NH, Souto AL, de Figueiredo PT, Siqueira-Junior JP, Tavares JF. Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species. Microb Pathog. 2017 Mar;104:151-154. doi: 10.1016/j.micpath.2017.01.028. Epub 2017 Jan 19. PubMed PMID: 28109770.

10: Deng X, Pu Q, Wang E, Yu C. Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms. Oncol Lett. 2016 Dec;12(6):5309-5314. doi: 10.3892/ol.2016.5317. Epub 2016 Oct 25. PubMed PMID: 28101244; PubMed Central PMCID: PMC5228217.

11: Eskandari EG, Doudi M, Abedi S. An in vitro study of antileishmanial effect of Portulaca oleracea extract. J Vector Borne Dis. 2016 Oct-Dec;53(4):362-369. PubMed PMID: 28035114.

12: Ma Y, Zhang Y, Zhai Y, Zhu Z, Pan Y, Qian D, Su S, Fan X, Duan J. Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism. Molecules. 2016 Dec 22;22(1). pii: E7. doi: 10.3390/molecules22010007. PubMed PMID: 28025523.

13: Li XJ, Zhu Z, Han SL, Zhang ZL. Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice. Int J Mol Med. 2016 Dec;38(6):1661-1672. doi: 10.3892/ijmm.2016.2794. Epub 2016 Nov 2. PubMed PMID: 27840967; PubMed Central PMCID: PMC5117769.

14: George S, Venkataraman R, Baby S. Melicodenine I, a new quinolinone alkaloid from Melicope denhamii leaves. Nat Prod Res. 2017 Apr;31(8):890-895. doi: 10.1080/14786419.2016.1253075. Epub 2016 Nov 6. PubMed PMID: 27817202.

15: Yu XA, Azietaku JT, Li J, An M, He J, Hao J, Cao J, Chang YX. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62. eCollection 2016. PubMed PMID: 27795734; PubMed Central PMCID: PMC5064970.

16: Wang C, Huo X, Tian X, Xu M, Dong P, Luan Z, Wang X, Zhang B, Zhang B, Huang S, Deng S, Ma X. Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model. Br J Pharmacol. 2016 Nov;173(22):3261-3275. doi: 10.1111/bph.13612. Epub 2016 Oct 10. PubMed PMID: 27588415; PubMed Central PMCID: PMC5071560.

17: Richardson JS, Sethi G, Lee GS, Malek SN. Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells. BMC Complement Altern Med. 2016 Oct 12;16(1):389. PubMed PMID: 27729078; PubMed Central PMCID: PMC5059921.

18: Fang K, Dong H, Jiang S, Li F, Wang D, Yang D, Gong J, Huang W, Lu F. Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells. Evid Based Complement Alternat Med. 2016;2016:7493694. doi: 10.1155/2016/7493694. Epub 2016 Aug 31. PubMed PMID: 27656241; PubMed Central PMCID: PMC5021865.

19: Bagchi VA, Siegel JP, Demkovich MR, Zehr LN, Berenbaum MR. Impact of Pesticide Resistance on Toxicity and Tolerance of Hostplant Phytochemicals in Amyelois Transitella (Lepidoptera: Pyralidae). J Insect Sci. 2016 Sep 12;16(1). pii: iew063. doi: 10.1093/jisesa/iew063. Print 2016. PubMed PMID: 27620560; PubMed Central PMCID: PMC5019020.

20: Wangchuk P, Giacomin PR, Pearson MS, Smout MJ, Loukas A. Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Sci Rep. 2016 Aug 30;6:32101. doi: 10.1038/srep32101. PubMed PMID: 27572696; PubMed Central PMCID: PMC5004179.