WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532958

CAS#: 405098-33-1

Description: W54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM).W54011 inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Chemical Structure

CAS# 405098-33-1

Theoretical Analysis

MedKoo Cat#: 532958
Name: W54011
CAS#: 405098-33-1
Chemical Formula: C30H36N2O2
Exact Mass: 456.28
Molecular Weight: 456.630
Elemental Analysis: C, 78.91; H, 7.95; N, 6.13; O, 7.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: W54011; W 54011; W-54011

IUPAC/Chemical Name: N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-(4-propan-2-ylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide


InChi Code: InChI=1S/C30H36N2O2/c1-21(2)23-11-16-26(17-12-23)32(20-22-9-14-25(15-10-22)31(3)4)30(33)28-8-6-7-24-13-18-27(34-5)19-29(24)28/h9-19,21,28H,6-8,20H2,1-5H3


Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 456.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Chmilewsky F, Jeanneau C, Laurent P, Kirschfink M, About I. Pulp progenitor cell recruitment is selectively guided by a C5a gradient. J Dent Res. 2013 Jun;92(6):532-9. doi: 10.1177/0022034513487377. Epub 2013 Apr 19. PubMed PMID: 23603337.

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9: Itoh S, Takeshita K, Susuki C, Shige-Eda K, Tsuji T. Redistribution of P-selectin ligands on neutrophil cell membranes and the formation of platelet-neutrophil complex induced by hemodialysis membranes. Biomaterials. 2008 Jul;29(21):3084-90. doi: 10.1016/j.biomaterials.2008.04.018. Epub 2008 May 2. PubMed PMID: 18452987.

10: Hama H, Ono N, Abe M. [Study for an allergic inflammation model using human lungs and its pharmacological application]. Yakugaku Zasshi. 2007 Apr;127(4):721-7. Review. Japanese. PubMed PMID: 17409703.

11: Sumichika H, Sakata K, Sato N, Takeshita S, Ishibuchi S, Nakamura M, Kamahori T, Ehara S, Itoh K, Ohtsuka T, Ohbora T, Mishina T, Komatsu H, Naka Y. Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem. 2002 Dec 20;277(51):49403-7. Epub 2002 Oct 15. PubMed PMID: 12384495.