YF-452

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525861

CAS#: 1951466-83-3

Description: YF-452 is a novel inhibitor of tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling.


Chemical Structure

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YF-452
CAS# 1951466-83-3

Theoretical Analysis

MedKoo Cat#: 525861
Name: YF-452
CAS#: 1951466-83-3
Chemical Formula: C24H26BrN3O
Exact Mass: 451.1259
Molecular Weight: 452.396
Elemental Analysis: C, 63.72; H, 5.79; Br, 17.66; N, 9.29; O, 3.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: YF-452

IUPAC/Chemical Name: N-(N-Pyrrolidylacetyl)-9-(4-bromobenzyl)-1,3,4,9-tetrahydro-ß-carboline

InChi Key: WIRUYQFUVBBWPT-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26BrN3O/c25-19-9-7-18(8-10-19)15-28-22-6-2-1-5-20(22)21-11-14-27(16-23(21)28)24(29)17-26-12-3-4-13-26/h1-2,5-10H,3-4,11-17H2

SMILES Code: BrC(C=C1)=CC=C1CN(C2=C3CCN(C(CN4CCCC4)=O)C2)C5=C3C=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 452.396 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu Y, He Y, Yang F, Cong X, Wang J, Peng S, Gao D, Wang W, Lan L, Ying X, Liu M, Chen Y, Yi Z. A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Sci China Life Sci. 2017 Feb;60(2):202-214. doi: 10.1007/s11427-016-0369-6. Epub 2017 Feb 13. PubMed PMID: 28194552.