Auten-99 HBr
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MedKoo CAT#: 525853

CAS#: 1049780-58-6 (HBr)

Description: Auten-99 HBr is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14) that has been shown to cross the blood-brain barrier and exert potent neuroprotective effects.

Chemical Structure

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Auten-99 HBr
CAS# 1049780-58-6 (HBr)
Instruction

Theoretical Analysis

MedKoo Cat#: 525853
Name: Auten-99 HBr
CAS#: 1049780-58-6 (HBr)
Chemical Formula: C17H15BrN2S
Exact Mass: 358.01
Molecular Weight: 359.280
Elemental Analysis: C, 56.83; H, 4.21; Br, 22.24; N, 7.80; S, 8.92

Price and Availability

Size Price Availability Quantity
5mg USD 265 2 Weeks
10mg USD 430 2 Weeks
25mg USD 750 2 Weeks
50mg USD 1095 2 Weeks
100mg USD 1750 2 Weeks
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Related CAS #: 904054-02-0 (free base)   1049780-58-6 (HBr)    

Synonym: Auten-99; Auten 99; Auten99; Auten-99 hydrochloride. Auten-99 HBr.

IUPAC/Chemical Name: 2-Biphenyl-4-yl-5,6-dihydro-imidazo[2,1-b]thiazole hydrobromide

InChi Key: FYYVGPJPIJHFCL-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14N2S.BrH/c1-2-4-13(5-3-1)14-6-8-15(9-7-14)16-12-19-11-10-18-17(19)20-16;/h1-9,12H,10-11H2;1H

SMILES Code: [H]Br.C12=NCCN1C=C(C3=CC=C(C4=CC=CC=C4)C=C3)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PMID: 28205624; PMCID: PMC5311965.


2: Komlós M, Szinyákovics J, Falcsik G, Sigmond T, Jezsó B, Vellai T, Kovács T. The Small-Molecule Enhancers of Autophagy AUTEN-67 and -99 Delay Ageing in Drosophila Striated Muscle Cells. Int J Mol Sci. 2023 Apr 30;24(9):8100. doi: 10.3390/ijms24098100. PMID: 37175806; PMCID: PMC10179358.