WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532898
Description: VU0240382 is an allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5.
MedKoo Cat#: 532898
Chemical Formula: C17H13NO
Exact Mass: 247.0997
Molecular Weight: 247.3
Elemental Analysis: C, 82.57; H, 5.30; N, 5.66; O, 6.47
This product is not in stock, which may be available by custom synthesis.
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Synonym: VU0240382, VU-0240382, VU 0240382
IUPAC/Chemical Name: 6-(2-phenylethynyl)-1,2,3,4-tetrahydroisoquinolin-1-one
InChi Key: BOVJHNHRQNCDEQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13NO/c19-17-16-9-8-14(12-15(16)10-11-18-17)7-6-13-4-2-1-3-5-13/h1-5,8-9,12H,10-11H2,(H,18,19)
SMILES Code: O=C1NCCC2=C1C=CC(C#CC3=CC=CC=C3)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 247.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, Conn PJ. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol. 2012 Feb;81(2):120-33. doi: 10.1124/mol.111.075184. Epub 2011 Oct 21. PubMed PMID: 22021324; PubMed Central PMCID: PMC3263948.