WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532896
Description: VU0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC₅₀ = 798 and 693 nM at human and rat mGlu4 receptors respectively). VU0155041 is active in in vivo models of Parkinson's disease.
MedKoo Cat#: 532896
Chemical Formula: C14H15Cl2NO3
Exact Mass: 315.0429
Molecular Weight: 316.18
Elemental Analysis: C, 53.18; H, 4.78; Cl, 22.42; N, 4.43; O, 15.18
Related CAS #: 1093757-42-6 (free) 1259372-69-4 (sodium salt)
Synonym: VU0155041, VU 0155041, VU-0155041
IUPAC/Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
InChi Key: VSMUYYFJVFSVCA-NWDGAFQWSA-N
InChi Code: InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1
SMILES Code: O=C([C@H]1[C@@H](C(NC2=CC(Cl)=CC(Cl)=C2)=O)CCCC1)O
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 316.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Domin H, Przykaza Ł, Jantas D, Kozniewska E, Boguszewski PM, Śmiałowska M. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94. doi: 10.1016/j.neuropharm.2015.11.025. Epub 2015 Dec 2. PubMed PMID: 26647070.