SW106

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525790

CAS#: 933452-76-7

Description: SW106 is a novel selective antagonist of PTHR1-mediated cAMP signaling, not functioning as an inverse agonist on either PTHR1-H223R or PTHR1-T410P, which have activating mutations at the cytoplasmic ends of TMD helices-2 and -6, respectively.


Chemical Structure

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SW106
CAS# 933452-76-7

Theoretical Analysis

MedKoo Cat#: 525790
Name: SW106
CAS#: 933452-76-7
Chemical Formula: C16H14F5NO2
Exact Mass: 347.0945
Molecular Weight: 347.285
Elemental Analysis: C, 55.34; H, 4.06; F, 27.35; N, 4.03; O, 9.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SW106; SW-106; SW 106;

IUPAC/Chemical Name: (3S,5S)-5-[(1E)-2-Cyclopropylethenyl]-6,7-difluoro-1,5-dihydro-3-methyl-5-(trifluoromethyl)-4,1-benzoxazepin-2(3H)-one

InChi Key: YLCLGDNMRKSMDS-CJGUPOHFSA-N

InChi Code: InChI=1S/C16H14F5NO2/c1-8-14(23)22-11-5-4-10(17)13(18)12(11)15(24-8,16(19,20)21)7-6-9-2-3-9/h4-9H,2-3H2,1H3,(H,22,23)/b7-6+/t8-,15-/m0/s1

SMILES Code: O=C1NC2=CC=C(F)C(F)=C2[C@](C(F)(F)F)(/C=C/C3CC3)O[C@H]1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 347.285 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29(2):307-21. doi: 10.1210/me.2014-1129. Epub 2015 Jan 13. PubMed PMID: 25584411; PubMed Central PMCID: PMC4318877.

2: Carter PH, Liu RQ, Foster WR, Tamasi JA, Tebben AJ, Favata M, Staal A, Cvijic ME, French MH, Dell V, Apanovitch D, Lei M, Zhao Q, Cunningham M, Decicco CP, Trzaskos JM, Feyen JH. Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51. Epub 2007 Apr 11. PubMed PMID: 17428923; PubMed Central PMCID: PMC1871873.

3: Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res. 2005 Feb 24;33(4):e36. PubMed PMID: 15731329; PubMed Central PMCID: PMC549575.