WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525778
Description: XIE18-6 is a novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein and promoting human and murine hematopoietic stem cell ex vivo expansion.
MedKoo Cat#: 525778
Chemical Formula: C18H15NO6S
Exact Mass: 373.062
Molecular Weight: 373.379
Elemental Analysis: C, 57.90; H, 4.05; N, 3.75; O, 25.71; S, 8.59
This product is not in stock, which may be available by custom synthesis.
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Synonym: XIE18-6, XIE18 6, XIE186
IUPAC/Chemical Name: 4-Acetylamino-benzenesulfonic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
InChi Key: LOMKFWDFEIQKOS-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H15NO6S/c1-11-9-18(21)24-17-10-14(5-8-16(11)17)25-26(22,23)15-6-3-13(4-7-15)19-12(2)20/h3-10H,1-2H3,(H,19,20)
SMILES Code: O=S(C1=CC=C(NC(C)=O)C=C1)(OC2=CC(O3)=C(C=C2)C(C)=CC3=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 373.379 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xie XQ, Yang P, Zhang Y, Zhang P, Wang L, Ding Y, Yang M, Tong Q, Cheng H, Ji Q, McGuire T, Yuan W, Cheng T, Gao Y. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115. doi: 10.1038/srep18115. PubMed PMID: 26681454; PubMed Central PMCID: PMC4683533.