WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525763
Description: 6jc48-1 is a novel inhibitor of Lipid II with less cytotoxicity and improved pharmacokinetic profile.
MedKoo Cat#: 525763
Chemical Formula: C27H22BBr2F4NO
Exact Mass: 621.0097
Molecular Weight: 623.0906
Elemental Analysis: C, 52.05; H, 3.56; B, 1.73; Br, 25.65; F, 12.20; N, 2.25; O, 2.57
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IUPAC/Chemical Name: 2,4-Bis-(4-bromo-phenyl)-6-[2-(4-dimethylamino-phenyl)-vinyl]-pyranylium;tetrafluoroborate
InChi Key: HQIFHNMTFIBILI-SYRJXDITSA-N
InChi Code: InChI=1S/C27H22Br2NO.BF4/c1-30(2)25-14-3-19(4-15-25)5-16-26-17-22(20-6-10-23(28)11-7-20)18-27(31-26)21-8-12-24(29)13-9-21;2-1(3,4)5/h3-18H,1-2H3;/q+1;-1/b16-5+;
SMILES Code: F[B-](F)(F)F.CN(C1=CC=C(/C=C/C2=[O+]C(C3=CC=C(Br)C=C3)=CC(C4=CC=C(Br)C=C4)=C2)C=C1)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 623.0906 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chauhan J, Cardinale S, Fang L, Huang J, Kwasny SM, Pennington MR, Basi K, diTargiani R, Capacio BR, MacKerell AD Jr, Opperman TJ, Fletcher S, de Leeuw EP. Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics. PLoS One. 2016 Oct 24;11(10):e0164515. doi: 10.1371/journal.pone.0164515. eCollection 2016. PubMed PMID: 27776124; PubMed Central PMCID: PMC5077133.