All Products

Featured Products

Newest Products

Research Areas

LDN-0212320 Maleate
new

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525692

CAS#: 894002-50-7

Description: LDN-0212320 Maleate is a novel activator of glutamate transporter EAAT2 translation.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 240 2 Weeks
25mg USD 450 2 Weeks
50mg USD 790 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-20. Prices are subject to change without notice.

LDN-0212320 Maleate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS docum ents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 525692
Name: LDN-0212320 Maleate
CAS#: 894002-50-7
Chemical Formula: C21H19N3O4S
Exact Mass: 409.1096
Molecular Weight: 409.46
Elemental Analysis: C, 61.60; H, 4.68; N, 10.26; O, 15.63; S, 7.83


Synonym: LDN-0212320 Maleate

IUPAC/Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine maleate

InChi Key: QIGJQEQXFAVIPF-BTJKTKAUSA-N

InChi Code: InChI=1S/C17H15N3S.C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15;5-3(6)1-2-4(7)8/h2-11H,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: CC1=CC=CC=C1CSC2=NN=C(C3=NC=CC=C3)C=C2.O=C(O)/C=C\C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Arendowski A, Ruman T. Laser Desorption/Ionisation Mass Spectrometry Imaging of European Yew (Taxus baccata) on Gold Nanoparticle-enhanced Target. Phytochem Anal. 2017 May 19. doi: 10.1002/pca.2693. [Epub ahead of print] PubMed PMID: 28523824.

2: Hirahara M, Fujiwara N, Seo K. Novel trigeminal slice preparation method for studying mechanisms of nociception transmission. J Neurosci Methods. 2017 May 15. pii: S0165-0270(17)30146-2. doi: 10.1016/j.jneumeth.2017.05.019. [Epub ahead of print] PubMed PMID: 28522210.

3: Kim SY, Park S, Yoo S, Rho JK, Jun ES, Chang S, Kim KK, Kim SC, Kim I. Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Oncotarget. 2017 May 12. doi: 10.18632/oncotarget.17841. [Epub ahead of print] PubMed PMID: 28521307.

4: Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Unusual Root Canal Irrigation Solutions. J Contemp Dent Pract. 2017 May 1;18(5):415-420. PubMed PMID: 28512283.

5: Mizoue S, Nitta K, Shirakashi M, Nitta A, Yamabayashi S, Kimura T, Ueda T, Takeda R, Matsumoto S, Yoshikawa K. Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1% and Timolol Maleate 0.5% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma. Adv Ther. 2017 May 15. doi: 10.1007/s12325-017-0552-5. [Epub ahead of print] PubMed PMID: 28508306.

6: Wang B, Wang Y, Wu Q, Huang HP, Li S. Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression. Front Neurosci. 2017 May 1;11:243. doi: 10.3389/fnins.2017.00243. eCollection 2017. PubMed PMID: 28507504; PubMed Central PMCID: PMC5410613.

7: Zhang L, Wu HW, Yuan W, Zheng JW. Propranolol therapy for infantile hemangioma: our experience. Drug Des Devel Ther. 2017 May 8;11:1401-1408. doi: 10.2147/DDDT.S134808. eCollection 2017. PubMed PMID: 28507428; PubMed Central PMCID: PMC5428756.

8: Battistini FD, Tártara LI, Boiero C, Guzmán ML, Luciani-Giaccobbe LC, Palma SD, Allemandi DA, Manzo RH, Olivera ME. The role of hyaluronan as a drug carrier to enhance the bioavailability of extended release ophthalmic formulations. Hyaluronan-timolol ionic complexes as a model case. Eur J Pharm Sci. 2017 May 12;105:188-194. doi: 10.1016/j.ejps.2017.05.020. [Epub ahead of print] PubMed PMID: 28506871.

9: Raczak-Gutknecht J, Frąckowiak T, Nasal A, Kornicka A, Sączewski F, Kaliszan R. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine? Dose Response. 2017 Apr 18;15(2):1559325817701213. doi: 10.1177/1559325817701213. eCollection 2017 Apr-Jun. PubMed PMID: 28491012; PubMed Central PMCID: PMC5405787.

10: Tawfeek HM, Faisal W, Soliman GM. Enalapril maleate orally disintegrating tablets: Tableting and in vivo evaluation in hypertensive rats. Pharm Dev Technol. 2017 May 10:1-25. doi: 10.1080/10837450.2017.1329318. [Epub ahead of print] PubMed PMID: 28489472.

11: Vijayan VM, Shenoy SJ, Muthu J. Octreotide-conjugated fluorescent PEGylated polymeric nanogel for theranostic applications. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:490-500. doi: 10.1016/j.msec.2017.03.125. Epub 2017 Mar 18. PubMed PMID: 28482555.

12: Ding Y, Su Y, Lv Z, Sun H, Bi X, Lu L, Zhou H, You Z, Wang Y, Ruan J, Gu P, Fan X. Poly (fumaroyl bioxirane) maleate: A potential functional scaffold for bone regeneration. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:249-259. doi: 10.1016/j.msec.2017.02.164. Epub 2017 Mar 2. PubMed PMID: 28482524.

13: Amiri M, Salavati-Niasari M, Pardakhty A, Ahmadi M, Akbari A. Caffeine: A novel green precursor for synthesis of magnetic CoFe(2)O(4) nanoparticles and pH-sensitive magnetic alginate beads for drug delivery. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1085-1093. doi: 10.1016/j.msec.2017.03.208. Epub 2017 Mar 24. PubMed PMID: 28482472.

14: Yen IC, Lee SY, Lin KT, Lai FY, Kuo MT, Chang WL. In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium. Molecules. 2017 May 6;22(5). pii: E747. doi: 10.3390/molecules22050747. PubMed PMID: 28481255.

15: Shikino K, Masuyama T, Yamashita T, Ikusaka M. Allergic contact dermatitis following drug rash due to chlorpheniramine maleate. Clin Case Rep. 2017 Mar 17;5(5):718-719. doi: 10.1002/ccr3.897. eCollection 2017 May. PubMed PMID: 28469883; PubMed Central PMCID: PMC5412794.

16: Guha M, Nguyen L, Poitout-Belissent F, Bedard A, Raman K. Salt Selection Matters: Differential Renal Toxicity With MDV1634.Maleate Versus MDV1634.2HCl. Int J Toxicol. 2017 Jan 1:1091581817704379. doi: 10.1177/1091581817704379. [Epub ahead of print] PubMed PMID: 28466691.

17: Saikia B, Barua CC, Haloi P, Patowary P. Anticholinergic, antihistaminic, and antiserotonergic activity of n-hexane extract of Zanthoxylum alatum seeds on isolated tissue preparations: An ex vivo study. Indian J Pharmacol. 2017 Jan-Feb;49(1):42-48. doi: 10.4103/0253-7613.201025. PubMed PMID: 28458421; PubMed Central PMCID: PMC5351237.

18: Schifani C, Sukhanov I, Dorofeikova M, Bespalov A. Novel reinforcement learning paradigm based on response patterning under interval schedules of reinforcement. Behav Brain Res. 2017 Apr 27. pii: S0166-4328(17)30143-2. doi: 10.1016/j.bbr.2017.04.043. [Epub ahead of print] PubMed PMID: 28457882.

19: Wei X, Pan Y, Xin X, Zheng C, Gao X, Xi J, Shang Q. Cross-resistance pattern and basis of resistance in a thiamethoxam-resistant strain of Aphis gossypii Glover. Pestic Biochem Physiol. 2017 May;138:91-96. doi: 10.1016/j.pestbp.2017.03.007. Epub 2017 Mar 22. PubMed PMID: 28456311.

20: Chen G, Lin X, Li G, Jiang D, Lib Z, Jiang R, Zhuo C. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomed Rep. 2017 Mar;6(3):285-290. doi: 10.3892/br.2017.850. Epub 2017 Jan 27. PubMed PMID: 28451387; PubMed Central PMCID: PMC5403402.